Cortical Gyrification Patterns Associated with Trait Anxiety.

PLoS One 2016 12;11(2):e0149434. Epub 2016 Feb 12.

Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, WI, United States of America.

Dispositional anxiety is a stable personality trait that is a key risk factor for internalizing disorders, and understanding the neural correlates of trait anxiety may help us better understand the development of these disorders. Abnormal cortical folding is thought to reflect differences in cortical connectivity occurring during brain development. Therefore, assessing gyrification may advance understanding of cortical development and organization associated with trait anxiety. Previous literature has revealed structural abnormalities in trait anxiety and related disorders, but no study to our knowledge has examined gyrification in trait anxiety. We utilized a relatively novel measure, the local gyrification index (LGI), to explore differences in gyrification as a function of trait anxiety. We obtained structural MRI scans using a 3T magnetic resonance scanner on 113 young adults. Results indicated a negative correlation between trait anxiety and LGI in the left superior parietal cortex, specifically the precuneus, reflecting less cortical complexity among those high on trait anxiety. Our findings suggest that aberrations in cortical gyrification in a key region of the default mode network is a correlate of trait anxiety and may reflect disrupted local parietal connectivity.

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0149434PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752488PMC
July 2016
36 Reads

Publication Analysis

Top Keywords

trait anxiety
36
anxiety
10
trait
10
cortical gyrification
8
associated trait
8
cortical
6
gyrification
5
complexity high
4
disorders study
4
structural abnormalities
4
anxiety disorders
4
abnormalities trait
4
high trait
4
examined gyrification
4
cortical complexity
4
anxiety utilized
4
gyrification trait
4
revealed structural
4
knowledge examined
4
study knowledge
4

Similar Publications