Multifunctional Gold-Mesoporous Silica Nanocomposites for Enhanced Two-Photon Imaging and Therapy of Cancer Cells.

Authors:
Dr. Jonas G Croissant, PhD
Dr. Jonas G Croissant, PhD
University of New Mexico, Chemical & Biological Engineering
Research Assistant Professor
Chemistry, Materials Science
Albuquerque, New Mexico | United States
Christian Qi
Christian Qi
Institut Charles Gerhardt Montpellier
Montpellier | France
Marie Maynadier
Marie Maynadier
NanoMedSyn
Montpellier | France
Laurence Raehm
Laurence Raehm
Institut Charles Gerhardt Montpellier
Montpellier | France
Olivier Mongin
Olivier Mongin
Université de Rennes 1
Rennes | France

Front Mol Biosci 2016 3;3. Epub 2016 Feb 3.

Institut Charles Gerhardt Montpellier, UMR-5253 CNRS-UM2-ENSCM-UM1 Montpellier, France.

Three dimensional sub-micron resolution has made two-photon nanomedicine a very promising medical tool for cancer treatment since current techniques cause significant side effects for lack of spatial selectivity. Two-photon-excited (TPE) photodynamic therapy (PDT) has been achieved via mesoporous nanoscaffolds, but the efficiency of the treatment could still be improved. Herein, we demonstrate the enhancement of the treatment efficiency via gold-mesoporous organosilica nanocomposites for TPE-PDT in cancer cells when compared to mesoporous organosilica particles. We performed the first comparative study of the influence of the shape and spatial position of gold nanoparticles (AuNPs) with mesoporous silica nanoparticles (MSN) functionalized with thiol groups and doped with a two-photon electron donor (2PS). The resulting multifunctional nanocarriers displayed TPE-fluorescence and were imaged inside cells. Furthermore, mesoporous organosilica NPs decorated gold nanospheres (AuNSs) induced 63 percent of selective killing on MCF-7 breast cancer cells. This study thus provides insights for the design of more effective multifunctional two-photon-sensitive nanocomposites via AuNPs for biomedical applications.

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Source
http://dx.doi.org/10.3389/fmolb.2016.00001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737918PMC

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February 2016
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