Modular Assembly Approach to Engineer Geometrically Precise Cardiovascular Tissue.

Adv Healthc Mater 2016 Apr 10;5(8):900-6. Epub 2016 Feb 10.

Laboratory for Stem Cells and Tissue Engineering, Department of Biomedical Engineering, Columbia University, New York, NY, 10027, USA.

This modular assembly approach to microfabricate functional cardiovascular tissue composites enables quantitative assessment of the effects of microarchitecture on cellular function. Cardiac and endothelial modules are micromolded separately, designed to direct cardiomyocyte alignment and anisotropic contraction or vascular network formation. Assembled cardiovascular tissue composites contract synchronously, facilitating the use of this tissue-engineering platform to study structure-function relationships in the heart.

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http://dx.doi.org/10.1002/adhm.201500956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836958PMC
April 2016
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References

(Supplied by CrossRef)

Gilbert et al.
Am. J. Physiol. Heart. Circ. Physiol. 2012

Pope et al.
Am. J. Physiol. Heart. Circ. Physiol. 2008

Sutton et al.
Circulation 2000

Mann et al.
Circulation 2005

Jessup et al.
N. Engl. J. Med. 2003

Kolewe et al.
Adv. Mater. 2013

McCain et al.
Proc. Natl. Acad. Sci. USA 2013

Frey et al.
Nat. Rev. Cardiol. 2012

Varnava et al.
Am. J. Cardiol. 2001

Rakusan et al.
Adv. Organ Biol. 1999

Porter et al.
Pharmacol. Ther. 2009

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