Diagnostics (Basel) 2012 Mar 20;2(1). Epub 2012 Mar 20.
Guest Editor, Biomedical Diagnostics Institute, National Centre of Sensor Research, School of Physical Sciences, Dublin City University, Glasnevin, Dublin 9, Ireland.
Download full-text PDF
Curr Pharm Biotechnol 2010 Jun;11(4):366-75
Superior NanoBioSystems LLC, 11722 Newbridge Court, Reston, VA, 20191, USA.
There are conditions in clinical medicine demanding critical therapeutic decisions. These conditions necessitate accuracy, rapidity, accessibility, cost-effectiveness and mobility. New technologies have been developed in order to address these challenges. Read More
Sensors (Basel) 2007 Sep 11;7(9):1901-1915. Epub 2007 Sep 11.
Department of Biochemistry and Microbiology, University of Laval, Quebec, Canada.
The desideratum to develop a fully integrated Lab-on-a-chip device capable ofrapid specimen detection for high throughput in-situ biomedical diagnoses and Point-of-Care testing applications has called for the integration of some of the novel technologiessuch as the microfluidics, microphotonics, immunoproteomics and Micro ElectroMechanical Systems (MEMS). In the present work, a silicon based microfluidic device hasbeen developed for carrying out fluorescence based immunoassay. By hybrid attachment ofthe microfluidic device with a Spectrometer-on-chip, the feasibility of synthesizing anintegrated Lab-on-a-chip type device for fluorescence based biosensing has beendemonstrated. Read More
Biotechnol Adv 2006 May-Jun;24(3):243-84. Epub 2005 Dec 2.
Micro-Energy System Laboratory, Guangzhou Institute of Energy Conversion, The Chinese Academy of Sciences, No. 1 Nengyuan Road, Wushan, Tianhe District, Guangzhou 510640, PR China.
The miniaturization of biological and chemical analytical devices by micro-electro-mechanical-systems (MEMS) technology has posed a vital influence on such fields as medical diagnostics, microbial detection and other bio-analysis. Among many miniaturized analytical devices, the polymerase chain reaction (PCR) microchip/microdevices are studied extensively, and thus great progress has been made on aspects of on-chip micromachining (fabrication, bonding and sealing), choice of substrate materials, surface chemistry and architecture of reaction vessel, handling of necessary sample fluid, controlling of three or two-step temperature thermocycling, detection of amplified nucleic acid products, integration with other analytical functional units such as sample preparation, capillary electrophoresis (CE), DNA microarray hybridization, etc. However, little has been done on the review of above-mentioned facets of the PCR microchips/microdevices including the two formats of flow-through and stationary chamber in spite of several earlier reviews [Zorbas, H. Read More
Lab Chip 2013 Jul 28;13(13):2438-40. Epub 2013 May 28.
The roots of lab on a chip in Canada are deep, comprising of some of the earliest contributions and first demonstrations of the potential of microfluidic chips. In an editorial leading off this special issue, Jed Harrison of University of Alberta reflects on these early days and Canada's role in the field's development (DOI: 10.1039/c3lc50522g). Read More