Clinical applications of circulating tumor DNA and circulating tumor cells in pancreatic cancer.

Mol Oncol 2016 Mar 22;10(3):481-93. Epub 2016 Jan 22.

Institut Curie, PSL Research University, SiRIC, Laboratory of Circulating Tumor Biomarkers, Paris, France; Institut Curie, PSL Research University, Department of Medical Oncology, Paris, France. Electronic address:

Pancreatic ductal adenocarcinoma (PDAC) is the most frequent pancreatic cancer type and is characterized by a dismal prognosis due to late diagnosis, local tumor invasion, frequent distant metastases and poor sensitivity to current therapy. In this context, circulating tumor cells and circulating tumor DNA constitute easily accessible blood-borne tumor biomarkers that may prove their clinical interest for screening, early diagnosis and metastatic risk assessment of PDAC. Moreover these markers represent a tool to assess PDAC mutational landscape. In this review, together with key biological findings, we summarize the clinical results obtained using "liquid biopsies" at the different stages of the disease, for early and metastatic diagnosis as well as monitoring during therapy.

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http://dx.doi.org/10.1016/j.molonc.2016.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528974PMC
March 2016
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Med. J. Aust 1869
Portal vein-circulating tumor cells predict liver metastases in patients with resectable pancreatic cancer
Bissolati et al.
Tumour Biol. J. Int. Soc. Oncodevelopmental Biol. Med 2015

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