Quantifying the utility of single nucleotide polymorphisms to guide colorectal cancer screening.

Future Oncol 2016 Feb 1;12(4):503-13. Epub 2016 Feb 1.

Centre for Epidemiology & Biostatistics, Melbourne School of Population & Global Health, The University of Melbourne, Parkville Victoria, VIC 3010, Australia.

Aim: To determine whether single nucleotide polymorphisms (SNPs) can be used to identify people who should be screened for colorectal cancer.

Methods: We simulated one million people with and without colorectal cancer based on published SNP allele frequencies and strengths of colorectal cancer association. We estimated 5-year risks of colorectal cancer by number of risk alleles.

Results: We identified 45 SNPs with an average 1.14-fold increase colorectal cancer risk per allele (range: 1.05-1.53). The colorectal cancer risk for people in the highest quintile of risk alleles was 1.81-times that for the average person.

Conclusion: We have quantified the extent to which known susceptibility SNPs can stratify the population into clinically useful colorectal cancer risk categories.

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Source
http://dx.doi.org/10.2217/fon.15.303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976832PMC

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February 2016
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References

(Supplied by CrossRef)
Article in Ann. Oncol.
Vasen HF et al.
Ann. Oncol. 2009

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