New cytotoxic cyclic peroxide acids from sp. marine sponge.

Authors:
Thomas R Hoye
Thomas R Hoye
University of Minnesota
Minneapolis | United States
Walied M Alarif
Walied M Alarif
King Abdulaziz University
Saudi Arabia
Salim S Basaif
Salim S Basaif
King Abdulaziz University
Mark T Hamann
Mark T Hamann
University
United States
Amir E Wahba
Amir E Wahba
The University of Mississippi
United States
Seif-Eldin N Ayyad
Seif-Eldin N Ayyad
King Abdulaziz University
Saudi Arabia

ARKIVOC 2015;2015(5):164-175. Epub 2015 Apr 5.

Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia; Department of Chemistry, Faculty of Science, Damietta University, Damietta, Egypt.

Bioassay-guided fractionation of the extract of Jamaican marine sponge sp. followed by preparative TLC and HPLC yielded several known methyl ester cyclic peroxides (), known plakortides (), known bicyclic lactone () and new cyclic peroxide acids (). The chemical structures were elucidated by extensive interpretation of their spectroscopic data. These natural products showed remarkable in vitro cytotoxicity against several cancer cell lines.

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Source
http://dx.doi.org/10.3998/ark.5550190.p008.948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732738PMC
April 2015
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