Influenza vaccine effectiveness in general practice and in hospital patients in Victoria, 2011-2013.

Authors:
Heath A Kelly
Heath A Kelly
University of Melbourne
Australia
Courtney Lane
Courtney Lane
Louisiana State University
Allen C Cheng
Allen C Cheng
Monash University
Australia

Med J Aust 2016 02;204(2):76

Alfred Health, Melbourne, VIC.

Objective: To compare influenza vaccine effectiveness in the general practice and hospital settings.

Design: Analysis of annual case test-negative studies.

Setting: Victorian sentinel hospitals and general practices, 2011-2013.

Participants: Patients presenting to general practitioners, or those admitted to hospital with an influenza-like illness who were tested for influenza using a polymerase chain reaction assay. Cases were patients with a positive test result for influenza; non-cases (controls) had a negative test result.

Main Outcome Measures: Vaccine effectiveness against laboratory-confirmed influenza.

Results: Hospitalised patients were on average older and reported a higher proportion of comorbidities than general practice patients. The pooled estimate of influenza vaccine effectiveness against laboratory-confirmed infection for the 3 years was 50% (95% CI, 26%-66%) for general practice patients and 39% (95% CI, 28%-47%) for patients admitted to hospital.

Conclusions: Influenza vaccines appeared to be similarly modestly effective in the general practice and hospital settings. Influenza vaccination appears to prevent hospital admission by preventing symptomatic infection rather than by attenuating the severity of illness.

Download full-text PDF

Source

Still can't find the full text of the article?

We can help you send a request to the authors directly.
February 2016
6 Reads

Publication Analysis

Top Keywords

general practice
20
vaccine effectiveness
16
influenza vaccine
12
practice hospital
12
effectiveness laboratory-confirmed
8
effectiveness general
8
practice patients
8
influenza
7
general
7
patients
7
hospital
5
practice
5
reported higher
4
older reported
4
average older
4
patients average
4
hospitalised patients
4
pooled estimate
4
estimate influenza
4
laboratory-confirmed infection
4

Similar Publications