Admission hyperuricemia increases the risk of acute kidney injury in hospitalized patients(.).

Authors:
Wisit Cheungpasitporn
Wisit Cheungpasitporn
Bassett Medical Center and Columbia University College of Physicians and Surgeons
United States
Charat Thongprayoon
Charat Thongprayoon
Mayo Clinic
Phoenix | United States
Dr Andrew M Harrison, MD, PhD
Dr Andrew M Harrison, MD, PhD
Mayo Clinic
Postdoctoral researcher
Clinical Informatics
Rochester, MN | United States
Stephen B Erickson

Clin Kidney J 2016 Feb 9;9(1):51-6. Epub 2015 Sep 9.

Division of Nephrology and Hypertension, Department of Medicine , Mayo Clinic , Rochester, MA , USA.

Background: The association between elevated admission serum uric acid (SUA) and risk of in-hospital acute kidney injury (AKI) is limited. The aim of this study was to assess the risk of developing AKI in all hospitalized patients with various admission SUA levels.

Methods: This is a single-center retrospective study conducted at a tertiary referral hospital. All hospitalized adult patients who had admission SUA available from January 2011 through December 2013 were analyzed in this study. Admission SUA was categorized based on its distribution into six groups (<3.4, 3.4-4.5, 4.5-5.8, 5.8-7.6, 7.6-9.4 and >9.4 mg/dL). The primary outcome was in-hospital AKI occurring after hospital admission. Logistic regression analysis was performed to obtain the odds ratio (OR) of AKI of various admission SUA levels using the most common SUA level range (5.8-7.6 mg/dL) as the reference group.

Results: Of 1435 patients enrolled, AKI occurred in 263 patients (18%). The incidence of AKI and need for dialysis was increased in patients with higher admission SUA levels. After adjusting for potential confounders, SUA >9.4 mg/dL was associated with an increased risk of developing AKI, with ORs of 1.79 [95% confidence interval (CI) 1.13-2.82]. Conversely, admission SUA <3.4 and 3.4-4.5 mg/dL were associated with a decreased risk of developing AKI, with ORs of 0.38 (95% CI 0.17-0.75) and 0.50 (95% CI 0.28-0.87), respectively.

Conclusions: Elevated admission SUA was associated with an increased risk for in-hospital AKI.

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Source
http://dx.doi.org/10.1093/ckj/sfv086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720187PMC

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February 2016
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References

(Supplied by CrossRef)
Acute kidney injury in cardiac surgery
Moguel-Gonzalez et al.
Rev Invest Clin 2013

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