Pharm Biol 2016 Sep 20;54(9):1503-12. Epub 2016 Jan 20.
a Department of Pharmaceutical Sciences , Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo , Hilo , HI , USA ;
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FASEB J 2010 Dec 9;24(12):4722-32. Epub 2010 Aug 9.
Division of Oncology, Washington University, School of Medicine, St. Louis, MO, USA.
Kava (Piper methysticum Foster, Piperaceae) organic solvent-extract has been used to treat mild to moderate anxiety, insomnia, and muscle fatigue in Western countries, leading to its emergence as one of the 10 best-selling herbal preparations. However, several reports of severe hepatotoxicity in kava consumers led the U.S. Read More
J Agric Food Chem 2015 Jul 10;63(28):6376-85. Epub 2015 Jul 10.
†Pharmaceutical Biology, Institute of Pharmacy, University of Regensburg, Universitätsstraße 31, 93053 Regensburg, Germany.
The in vitro metabolism of flavokawains A, B, and C (FKA, FKB, FKC), methoxylated chalcones from Piper methysticum, was examined using human liver microsomes. Phase I metabolism and phase II metabolism (glucuronidation) as well as combined phase I+II metabolism were studied. For identification and structure elucidation of microsomal metabolites, LC-HRESIMS and NMR techniques were applied. Read More
Toxicol Appl Pharmacol 2014 Jan 7;274(2):293-301. Epub 2013 Nov 7.
College of Pharmacy, Chosun University, Gwangju, 501-759, Republic of Korea. Electronic address:
Isorhamentin is a 3'-O-methylated metabolite of quercetin, and has been reported to have anti-inflammatory and anti-proliferative effects. However, the effects of isorhamnetin on Nrf2 activation and on the expressions of its downstream genes in hepatocytes have not been elucidated. Here, we investigated whether isorhamnetin has the ability to activate Nrf2 and induce phase II antioxidant enzyme expression, and to determine the protective role of isorhamnetin on oxidative injury in hepatocytes. Read More
Arch Toxicol 2013 Jan 5;87(1):167-78. Epub 2012 Aug 5.
Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan, ROC.
Chrysin, apigenin, and luteolin are flavones that differ in their number of hydroxyl groups in the B ring. In this study, we investigated the protection by chrysin, apigenin, and luteolin against tert-butyl hydroperoxide (tBHP)-induced oxidative stress and the possible mechanisms involved in rat primary hepatocytes. Chrysin, apigenin, and luteolin dose-dependently up-regulated the protein expression of heme oxygenase 1 (HO-1) and glutamate cysteine ligase (GCL) catalytic (GCLC) and modifier subunit (GCLM) and increased the intracellular glutathione (GSH) content and the ratio of GSH to oxidized GSH. Read More