Radiat Oncol 2016 Jan 19;11. Epub 2016 Jan 19.
Department of Radiology, University of Tokyo Hospital of Bunkyo-ku, Tokyo, Japan.
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Gan To Kagaku Ryoho 2009 Nov;36(12):1997-9
Department of Surgical Oncology, Osaka City University Graduate School of Medicine, and Department of Digestive Surgery, Osaka City General Hospital.
Background: Concurrent chemoradiotherapy (CRT) using cisplatin (CDDP) and 5-fluorouracil (5-FU) is the standard treatment for unresectable locally advanced esophageal carcinoma. Although this regimen has been widely accepted in Japan, the adverse effect of CDDP such as gastrointestinal and renal toxicity may sometimes be the cause of interruption of the treatment, especially among the elderly patients. Cis-diammine-glycolatoplatinum(nedaplatin: CDGP) is a new platinum agent, which was developed with the aim of decreasing renal and gastrointestinal toxicities but maintaining the effectiveness of CDDP. Read More
Int J Radiat Oncol Biol Phys 1998 Mar;40(5):1049-59
Department of Radiology, Tenri Hospital 200, Tenri City, Nara Prefecture, Japan.
Purpose: A prospective clinical trial was undertaken to investigate the feasibility of concurrent chemoradiotherapy for esophageal carcinomas.
Materials And Methods: Between June 1989 and May 1996, forty patients with operable squamous cell carcinoma of the thoracic esophagus (Stage 0 to III: UICC 1987), ages 45 to 78 years (mean: 64), were enrolled in a study of neoadjuvant concurrent chemoradiotherapy followed by definitive high-dose radiotherapy (CRT group) or surgery (CRT-S group). Neoadjuvant chemoradiotherapy consisted of 44 Gy in 40 fractions for 4 weeks (2. Read More
BMC Cancer 2009 Nov 22;9:408. Epub 2009 Nov 22.
First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Background: Protracted low-dose concurrent chemotherapy combined with radiation has been proposed for enhanced treatment results for esophageal cancer. We evaluated the efficacy and the toxicity of a novel regimen of daily low-dose nedaplatin (cis-diammine-glycolatoplatinum) and continuous infusion of 5-fluorouracil (5-FU) with radiation in patients with esophageal squamous cell carcinoma.
Methods: Between January 2003 and June 2008, 33 patients with clinical stage I to IVB esophageal squamous cell carcinoma were enrolled. Read More
Dis Esophagus 2010 Feb 9;23(2):160-7. Epub 2009 Jun 9.
Department of Oncology, I Medical Faculty of Charles University, 128 08 Prague, Czech Republic.
Combined modality treatment for esophageal carcinoma seems to improve survival over surgery alone. Different combinations of cytotoxic drugs have been studied to improve antitumor efficacy and limit the toxicity of chemoradiotherapy (CRT) with inconsistent results. We present a prospective study of neoadjuvant CRT with or without paclitaxel in chemotherapy schedule. Read More