Transfus Clin Biol 2016 Feb 6;23(1):5-12. Epub 2016 Jan 6.

Pôle biologie-pathologie-physiologie, CHU Saint-Louis, AP-HP, 75010 Paris, France. Electronic address:

Since its discovery, the human parvovirus B19 (B19V) has been associated with many clinical situations in addition to the prototype clinical manifestations, i.e. erythema infectiosum and erythroblastopenia crisis. The clinical significance of the viral B19V DNA persistence in sera after acute infection remains largely unknown. Such data may constitute a new clinical entity and is discussed in this manuscript. In 2002, despite the genetic diversity among B19V viruses has been reported to be very low, the description of markedly distinct sequences showed a new organization into three genotypes. The most recent common ancestor for B19V genotypes was estimated at early 1800s. B19V replication is enhanced by hypoxia and this might to explain the high viral load detected by quantitative PCR in the sera of infected patients. The minimum infectious dose necessary to transmit B19V infection by the transfusion of labile blood products remains unclear. At the opposite, the US Food and Drug Administration proposed a limit of 10(4)IU/mL of viral DNA in plasma pools used for the production of plasma derivatives. Recently, a new human parvovirus (PARV4) has been discovered. The consequences on blood transfusion of this blood-borne agent and its pathogenicity are still unknown.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tracli.2015.11.006DOI Listing
February 2016
9 Reads

Publication Analysis

Top Keywords

human parvovirus
12
parvovirus b19
8
b19v
6
explain high
4
high viral
4
hypoxia explain
4
enhanced hypoxia
4
1800s b19v
4
replication enhanced
4
viral load
4
b19v replication
4
detected quantitative
4
infected patients
4
patients minimum
4
minimum infectious
4
sera infected
4
pcr sera
4
early 1800s
4
quantitative pcr
4
load detected
4

Similar Publications

[Genetic diversity of human erythroviruses. Consequences on infectious safety of plasma derivatives].

Transfus Clin Biol 2009 Nov-Dec;16(5-6):482-8. Epub 2009 Oct 31.

Département des agents transmissibles par le sang, Institut national de la transfusion sanguine, 6, rue Alexandre-Cabanel, 75015 Paris, France.

The B19 Parvovirus (B19V) has for a long time been considered as the unique human virus belonging to the genus Erythrovirus. The genetic diversity of B19V isolates has been shown to be very low. The isolation of a variant (V9 strain), with a sequence markedly distinct from that of B19V which led to attributing this classification to this family of viruses. Read More

View Article
February 2010

Advances in human B19 erythrovirus biology.

J Virol 2010 Oct 14;84(19):9658-65. Epub 2010 Jul 14.

Département des Agents Transmissibles par le Sang, Institut National de la Transfusion Sanguine, Paris, France.

Since its discovery, human parvovirus B19 (B19V), now termed erythrovirus, has been associated with many clinical situations (neurological and myocardium infections, persistent B19V DNAemia) in addition to the prototype clinical manifestations, i.e., erythema infectiosum and erythroblastopenia crisis. Read More

View Article
October 2010

Existence of various human parvovirus B19 genotypes in Chinese plasma pools: genotype 1, genotype 3, putative intergenotypic recombinant variants and new genotypes.

Virol J 2016 09 17;13(1):155. Epub 2016 Sep 17.

Laboratory for Viral Safety of National Centre of Biomedical Analysis, Beijing Institute of Transfusion Medicine, No. 27 Taiping road, Haidian District, Beijing, 100850, China.

Background: Human parvovirus B19 (B19V) is a frequent contaminant of blood and plasma-derived medicinal products. Three distinct genotypes of B19V have been identified. The distribution of the three B19V genotypes has been investigated in various regions or countries. Read More

View Article
September 2016

Human Parvovirus B19 Utilizes Cellular DNA Replication Machinery for Viral DNA Replication.

J Virol 2018 03 12;92(5). Epub 2018 Feb 12.

Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA

Human parvovirus B19 (B19V) infection of human erythroid progenitor cells (EPCs) induces a DNA damage response and cell cycle arrest at late S phase, which facilitates viral DNA replication. However, it is not clear exactly which cellular factors are employed by this single-stranded DNA virus. Here, we used microarrays to systematically analyze the dynamic transcriptome of EPCs infected with B19V. Read More

View Article
March 2018