Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women.

Authors:
Yun-Chul Hong
Yun-Chul Hong
Seoul National University College of Medicine
Professor
Environmental Epidemiology
Seoul | Korea, Republic of
Zhaoming Wang Wei Jie Seow Kouya Shiraishi Chao A Hsiung Keitaro Matsuo Jie Liu Kexin Chen Taiki Yamji Yang Yang I-Shou Chang Chen Wu Laurie Burdett Kathleen Wyatt Charles C Chung Shengchao A Li Meredith Yeager Amy Hutchinson Wei Hu Neil Caporaso Maria T Landi Nilanjan Chatterjee Minsun Song Joseph F Fraumeni Takashi Kohno Jun Yokota Hideo Kunitoh Kyota Ashikawa Yukihide Momozawa Yataro Daigo Tetsuya Mitsudomi Yasushi Yatabe Toyoaki Hida Zhibin Hu Juncheng Dai Hongxia Ma Guangfu Jin Bao Song Zhehai Wang Sensen Cheng Zhihua Yin Xuelian Li Yangwu Ren Peng Guan Jiang Chang Wen Tan Chien-Jen Chen Gee-Chen Chang Ying-Huang Tsai Wu-Chou Su Kuan-Yu Chen Ming-Shyan Huang Yuh-Min Chen Hong Zheng Haixin Li Ping Cui Huan Guo Ping Xu Li Liu Motoki Iwasaki Taichi Shimazu Shoichiro Tsugane Junjie Zhu Gening Jiang Ke Fei Jae Yong Park Yeul Hong Kim Jae Sook Sung Kyong Hwa Park Young Tae Kim Yoo Jin Jung Chang Hyun Kang In Kyu Park Hee Nam Kim Hyo-Sung Jeon Jin Eun Choi Yi Young Choi Jin Hee Kim In-Jae Oh Young-Chul Kim Sook Whan Sung Jun Suk Kim Ho-Il Yoon Sun-Seog Kweon Min-Ho Shin Adeline Seow Ying Chen Wei-Yen Lim Jianjun Liu Maria Pik Wong Victor Ho Fun Lee Bryan A Bassig Margaret Tucker Sonja I Berndt Wong-Ho Chow Bu-Tian Ji Junwen Wang Jun Xu Alan Dart Loon Sihoe James C M Ho John K C Chan Jiu-Cun Wang Daru Lu Xueying Zhao Zhenhong Zhao Junjie Wu Hongyan Chen Li Jin Fusheng Wei Guoping Wu She-Juan An Xu-Chao Zhang Jian Su Yi-Long Wu Yu-Tang Gao Yong-Bing Xiang Xingzhou He Jihua Li Wei Zheng Xiao-Ou Shu Qiuyin Cai Robert Klein William Pao Charles Lawrence H Dean Hosgood Chin-Fu Hsiao Li-Hsin Chien Ying-Hsiang Chen Chung-Hsing Chen Wen-Chang Wang Chih-Yi Chen Chih-Liang Wang Chong-Jen Yu Hui-Ling Chen Yu-Chun Su Fang-Yu Tsai Yi-Song Chen Yao-Jen Li Tsung-Ying Yang Chien-Chung Lin Pan-Chyr Yang Tangchun Wu Dongxin Lin Baosen Zhou Jinming Yu Hongbing Shen Michiaki Kubo Stephen J Chanock Nathaniel Rothman Qing Lan

Hum Mol Genet 2016 Feb 4;25(3):620-9. Epub 2016 Jan 4.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.

Genome-wide association studies (GWAS) of lung cancer in Asian never-smoking women have previously identified six susceptibility loci associated with lung cancer risk. To further discover new susceptibility loci, we imputed data from four GWAS of Asian non-smoking female lung cancer (6877 cases and 6277 controls) using the 1000 Genomes Project (Phase 1 Release 3) data as the reference and genotyped additional samples (5878 cases and 7046 controls) for possible replication. In our meta-analysis, three new loci achieved genome-wide significance, marked by single nucleotide polymorphism (SNP) rs7741164 at 6p21.1 (per-allele odds ratio (OR) = 1.17; P = 5.8 × 10(-13)), rs72658409 at 9p21.3 (per-allele OR = 0.77; P = 1.41 × 10(-10)) and rs11610143 at 12q13.13 (per-allele OR = 0.89; P = 4.96 × 10(-9)). These findings identified new genetic susceptibility alleles for lung cancer in never-smoking women in Asia and merit follow-up to understand their biological underpinnings.

Download full-text PDF

Source
http://hmg.oxfordjournals.org/content/early/2016/01/06/hmg.d
Web Search
http://www.hmg.oxfordjournals.org/lookup/doi/10.1093/hmg/ddv
Publisher Site
http://dx.doi.org/10.1093/hmg/ddv494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731021PMC
February 2016
137 Reads
8 Citations
6.393 Impact Factor

Publication Analysis

Top Keywords

lung cancer
20
susceptibility loci
12
association studies
8
never-smoking women
8
genome-wide association
8
lung
5
cancer
5
significance marked
4
marked single
4
genome-wide significance
4
achieved genome-wide
4
three loci
4
loci achieved
4
single nucleotide
4
nucleotide polymorphism
4
snp rs7741164
4
rs7741164 6p211
4
per-allele odds
4
polymorphism snp
4
meta-analysis three
4

Similar Publications