Metab Syndr Relat Disord 2013 Dec 20;11(6):397-402. Epub 2013 Jul 20.
Department of General Medicine, Kasturba Medical College Hospital Attavar , Mangalore, Karnataka, India .
Introduction: The striking phenotypic similarities between metabolic syndrome and the Cushing syndrome of glucocorticoid excess have often been linked to 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which activates inert precursors like the cortisone, 11-dehydrocortisone to active glucocorticoids by oxo-reductase activity in several organs. Thus, increased expression of 11β-HSD1 is associated with insulin resistance, diabetes, hypertension, and dyslipidemia. In this study, we investigated the association of a common polymorphism of the HSD11B1 gene with metabolic syndrome and its components. Read More