Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation.

Nat Commun 2015 Dec 4;6:8658. Epub 2015 Dec 4.

Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester LE1 7RH, UK.

Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10(-8)) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.

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http://dx.doi.org/10.1038/ncomms9658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686825PMC
December 2015
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References

(Supplied by CrossRef)
Article in BMJ
DJ Hole et al.
BMJ 1996
Article in Eur. Respir. J.
RP Young et al.
Eur. Respir. J. 2007
Article in Eur. Respir. J.
AD Lopez et al.
Eur. Respir. J. 2006
Article in Lancet
R Lozano et al.
Lancet 2012
Article in Eur. Respir. J.
CJ Zappala et al.
Eur. Respir. J. 2010
Article in Am. J. Respir. Crit. Care Med.
DE Abbey et al.
Am. J. Respir. Crit. Care Med. 1998
Article in Genet. Epidemiol.
JB Wilk et al.
Genet. Epidemiol. 2000
Article in Eur. Respir. J.
LJ Palmer et al.
Eur. Respir. J. 2001
Article in Nat. Genet.
DB Hancock et al.
Nat. Genet. 2010
Article in Nat. Genet.
DW Loth et al.
Nat. Genet. 2014
Article in Nat. Genet.
E Repapi et al.
Nat. Genet. 2010

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