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J Gerontol A Biol Sci Med Sci 2021 Feb 27. Epub 2021 Feb 27.

University Hospital, Biochemistry and Molecular Genetic Department, Clermont-Ferrand, France.

Background: We previously assessed the inclusion of S100B blood determination into clinical decision rules for mild traumatic brain injury (mTBI) management in the Emergency Department (ED) of Clermont-Ferrand Hospital. At the 0.10 µg/L threshold, S100B reduced the use of cranial computed tomography (CCT) scan in adults by at least 30% with a ~100% sensitivity. Read More

ESMO Open 2021 Feb 26;6(2):100060. Epub 2021 Feb 26.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, USA.

Precision medicine is now pivotal to design patients' specific treatment strategies with the aim of prolonging progression and overall survival. In this regard, invasive tumor tissue testing has so far been the golden standard for making cancer diagnosis, but has limitations. Cell-free tumor DNA (ctDNA), a form of liquid biopsy, is a noninvasive biomarker that can be isolated from patients' blood and other biofluids. Read More

Biochem Pharmacol 2021 Feb 26:114491. Epub 2021 Feb 26.

Department of Pharmacology and Toxicology, Faculty of Medicine, The American University of Beirut, Beirut, Lebanon; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt; Faculty of Pharmacy, Alamein International University, Alamein City, Egypt. Electronic address:

Diabetic nephropathy is a major health challenge with considerable economic burden and significant impact on patients' quality of life. Despite recent advances in diabetic patient care, current clinical practice guidelines fall short of halting the progression of diabetic nephropathy to end-stage renal disease. Moreover, prior literature reported manifestations of renal dysfunction in early stages of metabolic impairment prior to the development of hyperglycemia indicating the involvement of alternative pathological mechanisms apart from those typically triggered by high blood glucose. Read More

Hemasphere 2021 Mar 23;5(3):e546. Epub 2021 Feb 23.

Institute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, Greece.

Gen Psychiatr 2021 8;34(1):e100289. Epub 2021 Feb 8.

Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: Atypical antipsychotics as first-line drugs have been used in patients with schizophrenia in China and abroad. However, its safety still needs to be evaluated in a large population, especially in Chinese patients.

Objective: The main objective of this study is to evaluate the safety and related factors of long-term atypical antipsychotic use in patients with schizophrenia in China. Read More