Habit-associated salivary pH changes in oral submucous fibrosis-A controlled cross-sectional study.

Authors:
Selvamani M
Selvamani M
College of Dental Sciences & Hospital
India
Dr. Mandana Donoghue, BDS, MDS, PGDHHM, PGDMLS
Dr. Mandana Donoghue, BDS, MDS, PGDHHM, PGDMLS
Independent
Researcher & Consultant
Oral & Maxillofacial Pathology & microbiology
Belgaum, Karnataka | India

J Oral Maxillofac Pathol 2015 May-Aug;19(2):175-81

Department of Oral and Maxillofacial Pathology and Microbiology, College of Dental Sciences, Davangere, Karnataka, India.

Context: Oral submucous fibrosis (OSF) is a multi-causal inflammatory reaction to the chemical or mechanical trauma caused due to exposure to arecanut containing products with or without tobacco (ANCP/T). Arecanut and additional components such as lime and chewing tobacco render ANCP/T highly alkaline. Fibrosing repair is a common reaction to an alkaline exposure in the skin. OSF may be related to the alkaline exposure by ANCP/T in a similar manner.

Aims: The study was aimed at establishing the relationship of habit-associated salivary pH changes and OSF.

Settings And Design: The study design was controlled cross-sectional.

Materials And Methods: Base line salivary pH (BLS pH), salivary pH after chewing the habitual ANCP/T substance, post chew salivary pH (PCSpH) for 2 min and salivary pH recovery time (SpHRT) were compared in 30 OSF patients and 30 sex-matched individuals with ANCP/T habits and apparently healthy oral mucosa.

Results: The group's mean BLSpH values were similar and within normal range and representative of the population level values. The average PCSpH was significantly higher (P ˂ 0.0001) than the average BLSpH in both groups. There was no significant difference (P = 0.09) between PCSpH of OSF patients and controls. OSF patients had a significantly longer (P = 0.0076) SpHRT than controls. Factors such as age, daily exposure, cumulative habit years, BLSpH and PCSpH, had varying effects on the groups.

Conclusions: Chewing ANCP/T causes a significant rise in salivary pH of all individuals. SpHRT has a significant association with OSF. The effect of salivary changes in OSF patients differs with those in healthy controls.

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Source
http://dx.doi.org/10.4103/0973-029X.164529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611925PMC
November 2015
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