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Biochem Biophys Res Commun 2020 08 8;529(1):119-125. Epub 2020 Jun 8.

Department of Experimental Medical Science, Lund University, Lund, Sweden. Electronic address:

Regulation of insulin signaling by microRNAs in smooth muscle cells may contribute to diabetic vascular disease. The two smooth muscle enriched miRNAs miR-143 and miR-145 have been reported to target mediators of insulin signaling in non-smooth muscle cells. In this study, we aimed to determine the importance of this regulation in vascular smooth muscle cells, where expression of miR-143/145 is much higher than in other cell types. Read More

J Mol Cell Biol 2020 02;12(2):152-162

Department of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Institute of Endocrinology and Diabetology, Fudan University, Shanghai, China.

Chronic inflammation plays a pivotal role in insulin resistance and type 2 diabetes, yet the mechanisms are not completely understood. Here, we demonstrated that serum LPS levels were significantly higher in newly diagnosed diabetic patients than in normal control. miR-145 level in peripheral blood mononuclear cells decreased in type 2 diabetics. Read More

Gene 2018 Dec 7;679:266-273. Epub 2018 Sep 7.

Department of Interventional Radiology, Tongji Hospital of Tongji University, Shanghai 200065, China. Electronic address:

Alterations in vascular smooth muscle cells (VSMCs) contribute to the pathogenesis of intracranial aneurysms (IAs), but the molecular mechanisms of these alterations are unclear. The aim of this study was therefore to identify the molecular mechanism of VSMC-mediated IAs at clinical and cellular levels. We used bioinformatic and biochemical analyses to show that the microRNA (miR)-143/145 cluster was involved in various biological processes related to aneurysm formation. Read More

Cardiovasc Pathol 2018 Nov - Dec;37:15-25. Epub 2018 Aug 23.

Department of Internal Medicine-Cardiovascular, Huaihe Hospital of Henan University. Electronic address:

Background: Excessive proliferation and migration of pulmonary artery smooth muscle cells (PASMCs) play an important role in the occurrence and development of pulmonary arterial hypertension (PAH). miR-143/145 was reported to be up-regulated in the animal models and PAH patients, and deletion of miR-143/145 cluster prevented the development of hypoxia-induced pulmonary hypertension, but its underlying mechanism has not been elucidated.

Methods: qRT-PCR and Western blot were performed to detect the expressions of miR-143/145 and ATP-binding cassette transporter A1 (ABCA1) in PAH patients and PASMCs under hypoxic conditions. Read More

J Microbiol Biotechnol 2016 Mar;26(3):572-8

Department of Cardiac Surgery, Zhongshan Hospital of Fudan University and Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, P.R. China.

Communication between endothelial cells (ECs) and smooth muscle cells (SMCs) via miR-143/145 clusters is vital to vascular stability. Previous research demonstrates that miR-143/145 released from ECs can regulate SMC proliferation and migration. In addition, a recent study has found that SMCs also have the capability of manipulating EC function via miR-143/145. Read More