Systematic Review of the Use of Phytochemicals for Management of Pain in Cancer Therapy.

Authors:
Dr Andrew M Harrison, MD, PhD
Dr Andrew M Harrison, MD, PhD
Mayo Clinic
Postdoctoral researcher
Clinical Informatics
Rochester, MN | United States
Fabrice Heritier
Fabrice Heritier
Regional Hospital
Fredonia | United States
Bennett G Childs
Bennett G Childs
Mayo Clinic
Phoenix | United States
Mikhail A Dziadzko
Mikhail A Dziadzko
Mayo Clinic
Rochester | United States

Biomed Res Int 2015 20;2015:506327. Epub 2015 Oct 20.

Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA.

Pain in cancer therapy is a common condition and there is a need for new options in therapeutic management. While phytochemicals have been proposed as one pain management solution, knowledge of their utility is limited. The objective of this study was to perform a systematic review of the biomedical literature for the use of phytochemicals for management of cancer therapy pain in human subjects. Of an initial database search of 1,603 abstracts, 32 full-text articles were eligible for further assessment. Only 7 of these articles met all inclusion criteria for this systematic review. The average relative risk of phytochemical versus control was 1.03 [95% CI 0.59 to 2.06]. In other words (although not statistically significant), patients treated with phytochemicals were slightly more likely than patients treated with control to obtain successful management of pain in cancer therapy. We identified a lack of quality research literature on this subject and thus were unable to demonstrate a clear therapeutic benefit for either general or specific use of phytochemicals in the management of cancer pain. This lack of data is especially apparent for psychotropic phytochemicals, such as the Cannabis plant (marijuana). Additional implications of our findings are also explored.

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http://dx.doi.org/10.1155/2015/506327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630373PMC

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August 2016
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References

(Supplied by CrossRef)
Article in Cochrane Database of Systematic Reviews
Cochrane Database of Systematic Reviews 2015

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