A comparative analysis of Patient-Reported Expanded Disability Status Scale tools.

Mult Scler 2016 09 12;22(10):1349-58. Epub 2015 Nov 12.

Clinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK/Wessex Neurosciences Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK

Background: Patient-Reported Expanded Disability Status Scale (PREDSS) tools are an attractive alternative to the Expanded Disability Status Scale (EDSS) during long term or geographically challenging studies, or in pressured clinical service environments.

Objectives: Because the studies reporting these tools have used different metrics to compare the PREDSS and EDSS, we undertook an individual patient data level analysis of all available tools.

Methods: Spearman's rho and the Bland-Altman method were used to assess correlation and agreement respectively.

Results: A systematic search for validated PREDSS tools covering the full EDSS range identified eight such tools. Individual patient data were available for five PREDSS tools. Excellent correlation was observed between EDSS and PREDSS with all tools. A higher level of agreement was observed with increasing levels of disability. In all tools, the 95% limits of agreement were greater than the minimum EDSS difference considered to be clinically significant. However, the intra-class coefficient was greater than that reported for EDSS raters of mixed seniority. The visual functional system was identified as the most significant predictor of the PREDSS-EDSS difference.

Conclusion: This analysis will (1) enable researchers and service providers to make an informed choice of PREDSS tool, depending on their individual requirements, and (2) facilitate improvement of current PREDSS tools.

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http://dx.doi.org/10.1177/1352458515616205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015760PMC
September 2016
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