Elevated glucose consumption and active lipogenesis are a common patho-physiological characteristic of cancer. We elutriated for the first time the link between glucose supply and sterol SREBP pathway, which controlling lipid metabolism. In this study, we delineate that EGFR signaling, by increasing glucose uptake, promotes SCAP N-glycosylation, and consequent proteolytic activation of SREBP.
SCAP acts as a key glucose-responsive protein to integrate oncogenic signaling and fuel availability for the control of lipid metabolism and tumor growth. Targeting SCAP N-glycosylation may provide a promising means of treating malignancies and metabolic diseases with deregulated lipid metabolism, such as atherosclerosis, obesity, and diabetes.
I spend the most energy on this study (this finding has been recognized by the American Cancer Society as one of “Ten Key Breakthroughs and Insights” in 2015). I hope this article can inspire or help more people to understand cancer. Starting from this finding, the deepening dig will help to kill cancer in the future.Dr. Chunming Cheng, PhD
Cancer Cell 2015 Nov;28(5):569-581
Department of Radiation Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA. Electronic address:
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