Molecular background of oligodendroglioma: 1p/19q, IDH, TERT, CIC and FUBP1.

CNS Oncol 2015 6;4(5):287-94. Epub 2015 Nov 6.

Southern Alberta Cancer Research Institute, University of Calgary, Calgary, AB T2N 1N4, Canada.

Oligodendroglioma is the quintessential molecularly-defined brain tumor. The characteristic whole-arm loss of the long arm of chromosome 1 and the short arm of chromosome 19 (1p/19q-codeletion) within the genome of these tumors facilitated the reproducible molecular identification of this subcategory of gliomas. More recently, recurrent molecular genetic alterations have been identified to occur concurrently with 1p/19q-codeletion, and definitively identify these tumors, including mutations in IDH1/2, CIC, FUBP1, and the TERT promoter, as well as the absence of ATRX and TP53 alterations. These findings provide a foundation for the consistent diagnosis of this tumor type, upon which a generation of clinical investigators have assembled a strong evidence base for the effective treatment of this disease with radiation and chemotherapy.

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http://dx.doi.org/10.2217/cns.15.32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082339PMC
August 2016
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