Crosstalk between stem cell and cell cycle machineries.

Curr Opin Cell Biol 2015 Dec 11;37:68-74. Epub 2015 Nov 11.

Department of Pathology, Stanford University, Stanford, CA 94305, USA; Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305, USA. Electronic address:

Pluripotent stem cells, defined by an unlimited self-renewal capacity and an undifferentiated state, are best typified by embryonic stem cells. These cells have a unique cell cycle compared to somatic cells as defined by a rapid progression through the cell cycle and a minimal time spent in G1. Recent reports indicate that pluripotency and cell cycle regulation are mechanistically linked. In this review, we discuss the reciprocal co-regulation of these processes, how this co-regulation may prevent differentiation, and how cellular reprogramming can re-establish the unique cell cycle regulation in induced pluripotent stem cells.

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http://dx.doi.org/10.1016/j.ceb.2015.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852861PMC
December 2015
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