Glucocorticoid signaling drives epigenetic and transcription factors to induce key regulators of human parturition.

Sci Signal 2015 Oct 27;8(400):fs19. Epub 2015 Oct 27.

First Department of Pediatrics, University of Athens Medical School, Athens 115 28, Greece.

Glucocorticoids are thought to play an important role in parturition. Two recent articles by Di Stefano et al. in the Archives and Wang et al. in this issue of Science Signaling reveal novel mechanisms by which glucocorticoid signaling can drive the epigenetic and transcriptional machinery to induce molecules involved in parturition, including the neuropeptide corticotropin-releasing hormone (CRH), the enzyme cyclooxygenase-2 (COX-2), and the autacoid hormone prostaglandin E2. These findings contribute to our understanding of how glucocorticoids may regulate human parturition.

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http://stke.sciencemag.org/lookup/doi/10.1126/scisignal.aad3
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http://dx.doi.org/10.1126/scisignal.aad3022DOI Listing
October 2015
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References

(Supplied by CrossRef)
Births: Final data for 2011
Martin et al.
Natl. Vital Stat. Rep. 2013
Maternal and fetal plasma cortisol levels at parturition
Goldkrand et al.
Obstet. Gynecol. 1976

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