Ugeskr Laeger 2015 10;177(42):V67470
Børneafdelingen, Afsnit for Hæmatologi og Onkologi, Aarhus Universitetshospital.
PLoS One 2021 6;16(5):e0250362. Epub 2021 May 6.
Institute for Ethics, History, and Philosophy of Medicine, Hannover Medical School, Hannover, Germany.
Objectives: Publication bias, non-publication, and selective reporting of animal studies limit progress toward the 3Rs (Replacement, Reduction, and Refinement) that guide ethical animal testing, waste public resources, and result in redundant research, which collectively undermine the public's trust in scientific reliability. In this study, we aimed to 1) validate findings from a previous follow-up study by our team that examined the publication rates of animal studies from protocol to publication and 2) identify incentives for improving publication rates in animal research.Methods: The researchers responsible for the animal proposals (n = 210) from our previous study were contacted as participants for a Web-based survey between October 2019 and April 2020. Read More
Acta Paediatr 2021 May 6. Epub 2021 May 6.
Department of Community Medicine and Rehabilitation, Forensic Medicine, Umeå University, Umeå, Sweden.
Benign external hydrocephalus (BEH) is a subtype of hydrocephalus. It is common in boys and characterised by rapid increases in head circumference (HC), enlarged subarachnoid spaces and normal or moderately enlarged ventricles. Most infants with BEH are born with a normal HC that starts to grow too rapidly after birth. Read More
Front Hum Neurosci 2021 19;15:644593. Epub 2021 Apr 19.
Neurologischen Klinik Universitätsklinikum Würzburg, Würzburg, Germany.
We estimate that 208,000 deep brain stimulation (DBS) devices have been implanted to address neurological and neuropsychiatric disorders worldwide. DBS Think Tank presenters pooled data and determined that DBS expanded in its scope and has been applied to multiple brain disorders in an effort to modulate neural circuitry. The DBS Think Tank was founded in 2012 providing a space where clinicians, engineers, researchers from industry and academia discuss current and emerging DBS technologies and logistical and ethical issues facing the field. Read More
BMJ Open 2021 May 5;11(5):e050682. Epub 2021 May 5.
Mount Sinai Hospital, Toronto, Ontario, Canada.
Introduction: Patent ductus arteriosus (PDA) is the most common cardiovascular problem that develops in preterm infants and evidence regarding the best treatment approach is lacking. Currently available medical options to treat a PDA include indomethacin, ibuprofen or acetaminophen. Wide variation exists in PDA treatment practices across Canada. Read More
BMJ Open 2021 May 5;11(5):e049964. Epub 2021 May 5.
Centre for Inflammation Research, Department of Child Life and Health, Royal Hospital for Children and Young People, Edinburgh, UK.
Introduction: Edinburgh and Lothians' Viral Intervention Study Kids is a parallel, open-label, randomised controlled trial of hypertonic saline (HS) nose drops (~2.6% sodium chloride) vs standard care in children <7 years of age with symptoms of an upper respiratory tract infection (URTI).Methods And Analysis: Children are recruited prior to URTI or within 48 hours of developing URTI symptoms by advertising in areas such as local schools/nurseries, health centres/hospitals, recreational facilities, public events, workplaces, local/social media. Read More