Effects of Nephrolithiasis on Serum DNase (Deoxyribonuclease I and II) Activity and E3 SUMO-Protein Ligase NSE2 (NSMCE2) in Malaysian Individuals.

Authors:
Atheer Awad Mehde, phD
Atheer Awad Mehde, phD
Sakarya University
Dr.
Sakarya | Turkey
wesen mehdi, phD
wesen mehdi, phD
Sakarya University
Dr.
sakarya | Turkey

Biomed Environ Sci 2015 Sep;28(9):660-5

Department of Pathology, Hospital Tengku Ampuan Afzan, Kuantan 25200, Malaysia.

Objective: Nephrolithiasis is one of the most common disorders of the urinary tract. The aim of this study was to examine a possible relationship between DNase I/II activity and E3 SUMO-protein ligase NSE2 in the sera of nephrolithiasis patients to evaluate the possibility of a new biomarker for evaluating kidney damage.

Methods: Sixty nephrolithiasis patients and 50 control patients were enrolled in a case-control study. Their blood urea, creatinine, protein levels and DNase I/II activity levels were measured by spectrometry. Serum NSMCE2 levels were measured by ELISA. Blood was collected from patients of the government health clinics in Kuantan-Pahang and fulfilled the inclusion criteria.

Results: The result indicated that mean levels of sera NSMCE2 have a significantly increase (P<0.01) in patients compared to control group. Compared with control subjects, activities and specific activities of serum DNase I and II were significantly elevated in nephrolithiasis patients (P$lt;0.01).

Conclusion: This study suggests that an increase in serum concentrations of DNase I/II and E3 SUMO-protein ligase NSE2 level can be used as indicators for the diagnosis of kidney injury in patients with nephrolithiasis.

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Source
http://dx.doi.org/10.3967/bes2015.092DOI Listing
September 2015
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