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Pharmaceutics 2021 Feb 27;13(3). Epub 2021 Feb 27.

Department of Applied Chemistry, Global Center for Pharmaceutical Ingredient Materials, Kyung Hee University, Seocheon, Giheung, Yongin, Gyeonggi-do 1732, Korea.

Even though spp. are staying commonly on human skin, it is also an opportunistic pathogenic fungus that can cause candidiasis. The emergence of resistant strains and the toxicity of antifungal agents have encouraged the development of new classes of potent antifungal agents. Read More

ChemistryOpen 2021 Feb 10;10(2):62-71. Epub 2020 Nov 10.

Anorganische Chemie, Institut fur Chemie, Universität Rostock, A.-Einstein-Str. 3a, 18059, Rostock, Germany.

Within the second funding period of the SPP 1708 "Material Synthesis near Room Temperature",which started in 2017, we were able to synthesize novel anionic species utilizing Ionic Liquids (ILs) both, as reaction media and reactant. ILs, bearing the decomposable and non-innocent methyl carbonate anion [CO Me] , served as starting material and enabled facile access to pseudohalide salts by reaction with Me Si-X (X=CN, N , OCN, SCN). Starting with the synthesized Room temperature Ionic Liquid (RT-IL) [nBu MeN][B(OMe) (CN)], we were able to crystallize the double salt [nBu MeN] [B(OMe) (CN)](CN). Read More

Org Biomol Chem 2021 01 12;19(4):770-774. Epub 2021 Jan 12.

Fakultät für Chemie und Biochemie, Ruhr-Universität Bochum, Universitätsstraße 150, 44801 Bochum, Germany.

A series of cationic monodentate and bidentate iodo(benz)imidazolium-based halogen bond (XB) donors were employed as catalysts in a Mukaiyama aldol reaction. While 5 mol% of a monodentate variant showed noticeable activity, a syn-preorganized bidentate XB donor provided a strong performance even with 0.5 mol% loading. Read More

Pharmaceuticals (Basel) 2020 Dec 21;13(12). Epub 2020 Dec 21.

Departamento de Química Inorgánica y Orgánica, Universitat Jaume I, Av. Sos Baynat s/n, 12071 Castellón, Spain.

The antibacterial activity of imidazole and imidazolium salts is highly dependent upon their lipophilicity, which can be tuned through the introduction of different hydrophobic substituents on the nitrogen atoms of the imidazole or imidazolium ring of the molecule. Taking this into consideration, we have synthesized and characterized a series of imidazole and imidazolium salts derived from -valine and -phenylalanine containing different hydrophobic groups and tested their antibacterial activity against two model bacterial strains, Gram-negative and Gram-positive . Importantly, the results demonstrate that the minimum bactericidal concentration (MBC) of these derivatives can be tuned to fall close to the cytotoxicity values in eukaryotic cell lines. Read More

ChemistryOpen 2021 Feb 23;10(2):243-247. Epub 2020 Dec 23.

Department of Physical Chemistry and Faculty of Interdisciplinary Research, Competence Centre CALOR, University of Rostock, Dr.-Lorenz-Weg 2, 18059, Rostock, Germany.

A series of nine different known ionic liquids or low melting salts was synthesised and purified. They are composed of the [NTf ] (bis(trifluoromethane)sulfonimide), [OTf] (trifluoro-methane-sulfonate), or [B(CN) ] (tetracyanidoborate) anion and [Ph P] (tetraphenylphosphonium), [Ph BzP] (triphenylbenzyl phosphonium), [ Bu P] (tetra- butylphosphonium), [ BuPh P] (tri-phenyl- butylphosphonium), [ Bu N] (tetra- butylammonium), or the [PPN] (bis(triphenylphosphine)iminium) cation. Precise vapour pressure data and enthalpies of vaporisation were measured using the Quartz Crystal Microbalance (QCM) method and evaluated. Read More