Prediction of Blood Pressure and Blood Pressure Change With a Genetic Risk Score.

J Clin Hypertens (Greenwich) 2016 Mar 5;18(3):181-6. Epub 2015 Oct 5.

Department of Health, National Institute for Health and Welfare, Turku/Helsinki, Finland.

The authors investigated whether a genetic risk score (GRS) constructed of 32 single nucleotide polymorphisms would predict incident hypertension and blood pressure (BP) change over time in a population cohort during an 11-year follow-up (n=5402 at baseline, 3266 at follow-up). In multivariable models, GRS was associated with higher systolic/diastolic BP values at baseline (β±standard error [SE], 1.04±0.14/1.11±0.13 mm Hg; P<.0001 for both) and at reinvestigation (β±SE, 0.84±0.18/0.79±0.16 mm Hg; P<.0001 for both). Among participants who were normotensive at baseline (n=2045), GRS was not independently associated with systolic/diastolic BP change over time (β±SE, 0.16±0.18/0.20±0.18 mm Hg; P≥.28 for both). In participants in the top tertile of the GRS, as compared with the bottom tertile, the predicted increase in systolic/diastolic BP was 1.18±0.78/0.70±0.49 mm Hg (P=.046/.15) greater and the odds ratio for incident hypertension was 33% higher (P=.03). These data show that GRS is strongly associated with BP but weakly associated with BP increase and incident hypertension in a late middle-aged population.

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http://dx.doi.org/10.1111/jch.12702DOI Listing
March 2016
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References

(Supplied by CrossRef)
Heritability and stability of resting blood pressure
Hottenga et al.
Twin Res Hum Genet 2005
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
International Consortium for Blood Pressure Genome-Wide Association Studies et al.
Nature 2011

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