Therapeutic efficacy of a polysaccharide isolated from Cordyceps sinensis on hypertensive rats.

Authors:

Feixiang Xiang Liming Lin Min Hu Xiangqian Qi

Int J Biol Macromol 2016 Jan 30;82:308-14. Epub 2015 Sep 30.

Department of Ultrasonography, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jiefang Street, Wuhan, China.

This study was aimed to investigate the antihypertensive effect of a polysaccharide fraction from Cordyceps sinensis on spontaneously hypertensive rats (SHR). The CSP1, one component of Cordyceps sinensis polysaccharides (CSP), was obtained after water extraction, deproteinization, de-colorization and purification with DEAE-cellulose 52. And a more homogeneous component CSP1-2 was obtained using Sepharose CL-6B chromatography. CSP1-2 mainly consisted of mannose, glucose and galactose in a molar ratio of about 2:2:1 and its average molecular weight was approximately 2.70×10(4)Da. Pharmacological tests showed that CSP1, in which the CSP1-2 was its main component, had antihypertensive effect by stimulating the secretion of vasodilator NO, decreasing the level of ET-1, epinephrine, noradrenaline and angiotensin II, inhibiting the increase of transforming growth factor β1 (TGF-β1) and lowering the level of inflammatory mediator of C-reactive protein (CRP). These results suggested that CSP1 may possess high potential in treating hypertension.

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http://dx.doi.org/10.1016/j.ijbiomac.2015.09.060	DOI Listing

January 2016

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