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Radiother Oncol 2021 Feb 18. Epub 2021 Feb 18.

Department of Radiation Oncology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Beijing Neurosurgery Institute, Capital Medical University, Beijing China.

Background And Purpose: The optimal target volume in localized basal ganglia (BG) germinoma is still undetermined. Thus, based on the relapse pattern and health-related quality of life (HRQOL), we evaluated three target volumes.

Material And Methods: The clinical data of 161 patients with localized BG germinoma were included in this retrospective study. Read More

Med Phys 2021 Jan 28. Epub 2021 Jan 28.

University of Grenoble Alpes, CNRS, TIMC-IMAG, F-38000, Grenoble, France.

Purpose: New radiation therapy protocols, in particular adaptive, focal or boost brachytherapy treatments, require determining precisely the position and orientation of the implanted radioactive seeds from real-time ultrasound (US) images. This is necessary to compare them to the planned one and to adjust automatically the dosimetric plan accordingly for next seeds implantations. The image modality, the small size of the seeds, and the artifacts they produce make it a very challenging problem. Read More

Int Cancer Conf J 2021 Jan 25;10(1):54-58. Epub 2020 Sep 25.

Department of Radiation Oncology, Tokyo Women's Medical University School of Medicine, 8-1, Kawada-cho, Shinjuku-ku, Tokyo, 162-8666 Japan.

Hepatocellular carcinoma (HCC) with extrahepatic metastasis is rare, and its prognosis is extremely poor. There is no standard treatment for HCC with extrahepatic metastasis. We report a case of abscopal effect in HCC with multiple pleural metastases in a patient who was treated with focal radiotherapy to extrahepatic metastasis, and achieved long-term survival. Read More

J Clin Oncol 2021 Mar 20;39(7):787-796. Epub 2021 Jan 20.

The Netherlands Cancer Institute, Radiation Oncology, Amsterdam, the Netherlands.

Purpose: This study investigates whether focal boosting of the macroscopic visible tumor with external beam radiotherapy increases biochemical disease-free survival (bDFS) in patients with localized prostate cancer.

Patients And Methods: In the phase III, multicenter, randomized controlled Focal Lesion Ablative Microboost in Prostate Cancer trial, 571 patients with intermediate- and high-risk prostate cancer were enrolled between 2009 and 2015. Patients assigned to standard treatment received 77 Gy (fractions of 2. Read More

Phys Imaging Radiat Oncol 2020 Jul 10;15:66-71. Epub 2020 Aug 10.

Oncology, Bristol Haematology and Oncology Centre, Bristol BS2 8ED, UK.

Background And Purpose: Radiotherapy dose painting is a promising technique which enables dose escalation to areas of higher tumour cell density within the prostate which are associated with radioresistance, known as dominant intraprostatic lesions (DILs). The aim of this study was to determine factors affecting the feasibility of radiotherapy dose painting in patients with high and intermediate risk prostate cancer.

Materials & Methods: Twenty patients were recruited into the study for imaging using a 3 T magnetic resonance imaging (MRI) scanner. Read More