Photoresponsive Bridged Silsesquioxane Nanoparticles with Tunable Morphology for Light-Triggered Plasmid DNA Delivery.

Authors:
Yevhen Fatieiev
Yevhen Fatieiev
Smart Hybrid Materials Laboratory (SHMs)
Dr. Jonas G Croissant, PhD
Dr. Jonas G Croissant, PhD
University of New Mexico, Chemical & Biological Engineering
Research Assistant Professor
Chemistry, Materials Science
Albuquerque, New Mexico | United States
Shahad Alsaiari
Shahad Alsaiari
Smart Hybrid Materials (SHMs) Laboratory
Dalaver H Anjum
Dalaver H Anjum
King Abdullah University of Science and Technology (KAUST)
Saudi Arabia
Niveen M Khashab
Niveen M Khashab
Smart Hybrid Materials Laboratory
United States

ACS Appl Mater Interfaces 2015 Nov 29;7(45):24993-7. Epub 2015 Sep 29.

Smart Hybrid Materials Laboratory, Imaging and Characterization Laboratory, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST) , Thuwal 23955-6900, Kingdom of Saudi Arabia.

Bridged silsesquioxane nanocomposites with tunable morphologies incorporating o-nitrophenylene-ammonium bridges are described. The systematic screening of the sol-gel parameters allowed the material to reach the nanoscale with controlled dense and hollow structures of 100-200 nm. The hybrid composition of silsesquioxanes with 50% organic content homogeneously distributed in the nanomaterials endowed them with photoresponsive properties. Light irradiation was performed to reverse the surface charge of nanoparticles from +46 to -39 mV via a photoreaction of the organic fragments within the particles, as confirmed by spectroscopic monitorings. Furthermore, such nanoparticles were applied for the first time for the on-demand delivery of plasmid DNA in HeLa cancer cells via light actuation.

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http://dx.doi.org/10.1021/acsami.5b07365DOI Listing

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November 2015
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