Ghana randomized air pollution and health study (GRAPHS): study protocol for a randomized controlled trial.

Authors:
Darby W Jack
Darby W Jack
Columbia University
United States
Kwaku Poku Asante
Kwaku Poku Asante
Albert Schweitzer Hospital
Blair J Wylie
Blair J Wylie
Massachusetts General Hospital and Harvard Medical School
Boston | United States
Robin M Whyatt
Robin M Whyatt
Columbia University
United States
Ashlinn K Quinn
Ashlinn K Quinn
Mailman School of Public Health
New York | United States
Abena Konadu Yawson
Abena Konadu Yawson
Kintampo Health Research Centre

Trials 2015 Sep 22;16:420. Epub 2015 Sep 22.

Kintampo Health Research Centre, Ghana Health Service, Brong Ahafo Region, Kintampo, Ghana.

Background: Household air pollution exposure is a major health risk, but validated interventions remain elusive.

Methods/design: The Ghana Randomized Air Pollution and Health Study (GRAPHS) is a cluster-randomized trial that evaluates the efficacy of clean fuels (liquefied petroleum gas, or LPG) and efficient biomass cookstoves in the Brong-Ahafo region of central Ghana. We recruit pregnant women into LPG, efficient cookstove, and control arms and track birth weight and physician-assessed severe pneumonia incidence in the first year of life. A woman is eligible to participate if she is in the first or second trimester of pregnancy and carrying a live singleton fetus, if she is the primary cook, and if she does not smoke. We hypothesize that babies born to intervention mothers will weigh more and will have fewer cases of physician-assessed severe pneumonia in the first year of life. Additionally, an extensive personal air pollution exposure monitoring effort opens the way for exposure-response analyses, which we will present alongside intention-to-treat analyses. Major funding was provided by the National Institute of Environmental Health Sciences, The Thrasher Research Fund, and the Global Alliance for Clean Cookstoves.

Discussion: Household air pollution exposure is a major health risk that requires well-tested interventions. GRAPHS will provide important new evidence on the efficacy of both efficient biomass cookstoves and LPG, and will thus help inform health and energy policies in developing countries.

Trial Registration: The trial was registered with clinicaltrials.gov on 13 April 2011 with the identifier NCT01335490 .

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Source
http://dx.doi.org/10.1186/s13063-015-0930-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579662PMC

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September 2015
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References

(Supplied by CrossRef)
Article in Lancet
SS Lim et al.
Lancet 2012
Article in Inhal Toxicol
LP Naeher et al.
Inhal Toxicol 2007
Article in Environ Health Perspect
ML Clark et al.
Environ Health Perspect 2013
Article in Bull World Health Organ
M Dherani et al.
Bull World Health Organ 2008
Article in Annu Rev Public Health
KR Smith et al.
Annu Rev Public Health 2014
Article in Thorax
OP Kurmi et al.
Thorax 2010
Article in Eur Respir J
OP Kurmi et al.
Eur Respir J 2012
Article in Epidemiol Rev
DP Pope et al.
Epidemiol Rev 2010
Article in Glob Heart
JP McCracken et al.
Glob Heart 2012
Article in Environ Health Perspect
KR Smith et al.
Environ Health Perspect 2010

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