Pretransplantation Minimal Residual Disease Predicts Survival in Patients with Mantle Cell Lymphoma Undergoing Autologous Stem Cell Transplantation in Complete Remission.

Biol Blood Marrow Transplant 2016 Feb 5;22(2):380-385. Epub 2015 Sep 5.

Clinical Research Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington. Electronic address:

Autologous stem cell transplantation (ASCT) is standard therapy for mantle cell lymphoma (MCL) in remission after induction chemotherapy, with the best results for patients in complete remission (CR). We hypothesized that evaluation of minimal residual disease (MRD) before ASCT could further stratify outcomes for these patients. Patients with MCL who underwent ASCT in clinical CR between 1996 and 2011 with pretransplantation MRD testing were eligible. Presence of a clonal IgH rearrangement, t(11; 14) by PCR or positive flow cytometry from blood or bone marrow, was considered positive. An adjusted proportional hazards model for associations with progression-free (PFS) and overall survival (OS) was performed. Of 75 MCL patients in CR, 8 (11%) were MRD positive. MRD positivity was associated with shorter OS and PFS. The median OS for MRD-negative patients was not reached, with 82% survival at 5 years, whereas for the MRD-positive patients, median OS was 3.01 years (hazard ratio [HR], 4.04; P = .009), with a median follow-up of 5.1 years. The median PFS for MRD-negative patients was not reached with 75% PFS at 5 years, whereas for MRD-positive patients, it was 2.38 years (HR, 3.69; P = .002). MRD positivity is independently associated with poor outcomes after ASCT for MCL patients in CR.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbmt.2015.08.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716882PMC
February 2016
40 Reads

Publication Analysis

Top Keywords

patients
10
complete remission
8
cell transplantation
8
stem cell
8
mcl patients
8
cell lymphoma
8
mrd-positive patients
8
mrd-negative patients
8
patients reached
8
mrd positivity
8
5 years mrd-positive
8
mantle cell
8
autologous stem
8
minimal residual
8
residual disease
8
mrd
5
11% mrd
4
mrd positive
4
survival performed
4
patients 11%
4

Similar Publications