A Systematic Review of Iran's Medicinal Plants With Anticancer Effects.

Authors:
Dr. Majid Asadi-Samani, PhD
Dr. Majid Asadi-Samani, PhD
Shahrekord University of Medical Sciences
Pharmacognosy
Wesam Kooti
Wesam Kooti
Ahvaz Jundishapur University of Medical Sciences
Iran
Elahe Aslani
Elahe Aslani
Islamic Azad University
Firuzabad | Iran
Hedayatollah Shirzad
Hedayatollah Shirzad
Shahrekord University of Medical Sciences
Iran

J Evid Based Complementary Altern Med 2016 Apr 21;21(2):143-53. Epub 2015 Aug 21.

Student Research Committee, Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran

Increase in cases of various cancers has encouraged the researchers to discover novel, more effective drugs from plant sources. This study is a review of medicinal plants in Iran with already investigated anticancer effects on various cell lines. Thirty-six medicinal plants alongside their products with anticancer effects as well as the most important plant compounds responsible for the plants' anticancer effect were introduced. Phenolic and alkaloid compounds were demonstrated to have anticancer effects on various cancers in most studies. The plants and their active compounds exerted anticancer effects by removing free radicals and antioxidant effects, cell cycle arrest, induction of apoptosis, and inhibition of angiogenesis. The investigated plants in Iran contain the compounds that are able to contribute effectively to fighting cancer cells. Therefore, the extract and active compounds of the medicinal plants introduced in this review article could open a way to conduct clinical trials on cancer and greatly help researchers and pharmacists develop new anticancer drugs.

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Source
http://dx.doi.org/10.1177/2156587215600873DOI Listing
April 2016
142 Reads
13 Citations

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References

(Supplied by CrossRef)
Article in Int J PharmTech Res
Agarwal N et al.
Int J PharmTech Res 2012

International Agency for Research on Cancer et al.
2014
Article in Continuum
Dropcho EJ et al.
Continuum 2011
Article in Int J PharmTech Res
Sakarkar DM et al.
Int J PharmTech Res 2011
Article in J Med Plants Res
Azadmehr A et al.
J Med Plants Res 2011

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