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NDM-1 (New Delhi metallo beta lactamase-1) producing Gram-negative bacilli: emergence & clinical implications.

Indian J Med Res 2014 Nov;140(5):672-8

Department of Microbiology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu & Kashmir, India.

Unlabelled: BACKGOUND & OBJECTIVES: Resistance to carbapenems in Gram-negative bacteria conferred by NDM-1 is a global health problem. We investigated the occurrence of NDM-1 in clinical isolates of Gram-negative bacilli in a tertiary care hospital in Kashmir valley, India.

Methods: Gram-negative bacilli from different clinical isolates were included in the study. Read More

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November 2014

Carbapenemase-producing Gram-negative bacteria: current epidemics, antimicrobial susceptibility and treatment options.

Future Microbiol 2015 ;10(3):407-25

Department of Emergency Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.

Carbapenemases, with versatile hydrolytic capacity against β-lactams, are now an important cause of resistance of Gram-negative bacteria. The genes encoding for the acquired carbapenemases are associated with a high potential for dissemination. In addition, infections due to Gram-negative bacteria with acquired carbapenemase production would lead to high clinical mortality rates. Read More

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January 2016

Emergence of Klebsiella pneumoniae co-producing NDM-type and OXA-181 carbapenemases.

Clin Microbiol Infect 2013 Sep 13;19(9):E421-3. Epub 2013 May 13.

Department of Laboratory Medicine, National University Hospital, Singapore City, Singapore.

The emergence of carbapenemase-producing Enterobacteriaceae is a rapidly evolving threat worldwide. Here, we report the molecular characterization of two Klebsiella pneumoniae isolates carrying both bla(OXA -181) and bla(NDM -1) or bla(NDM -5) isolated from epidemiologically unrelated patients in Singapore. The bla(OXA -181) genes were found existing in different genetic environments. Read More

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September 2013

Emerging carbapenemases: a global perspective.

Authors:
Timothy R Walsh

Int J Antimicrob Agents 2010 Nov;36 Suppl 3:S8-14

Cardiff University, Heath Park Hospital, UK.

The celestial rise in antibiotic resistance among Gram-negative bacteria has challenged both the scientific and pharmaceutical sectors. The hallmark of this general increase is the unbridled dissemination of carbapenem resistance genes, namely KPC, OXA and metallo-β-lactamase variants. In particular, the media attention given to the NDM-1 metallo-β-lactamase has highlighted the global consequences of human behaviour on spreading antibiotic resistance. Read More

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November 2010