A peptide-based pH-sensitive drug delivery system for targeted ablation of cancer cells.

Chem Commun (Camb) 2015 Oct;51(77):14454-7

Beijing National Laboratory for Molecular Sciences, CAS Key Laboratories of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.

A peptide-guided prodrug incorporating a tumor-specific peptide, doxorubicin, and a pH-sensitive hydrazone bridge was developed for targeted ablation of cancer cells with minimal side cytotoxicity.

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http://xlink.rsc.org/?DOI=C5CC05184C
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http://dx.doi.org/10.1039/c5cc05184cDOI Listing
October 2015
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