Endocrinol Diabetes Metab Case Rep 2015 17;2015:150038. Epub 2015 Jun 17.
Department of Pathology, Militar Medical Academy , Crnotravska 1711000, Belgrade , Serbia.
Download full-text PDF
Eur Thyroid J 2016 Dec 3;5(4):231-239. Epub 2016 Dec 3.
Department of Endocrinology and Diabetes, The Alfred Hospital, Monash University, Melbourne, VIC, Australia; Department of Medicine, Monash University, Melbourne, VIC, Australia.
Immunoglobulin G4-related disease (IgG4-RD) is a new disease category involving many organ systems, including the endocrine system in general and the thyroid in particular. Since an initial association was made between hypothyroidism and autoimmune (IgG4-related) pancreatitis, more forms of IgG4-related thyroid disease (IgG4-RTD) have been recognized. Four subcategories of IgG4-RTD have so far been identified: Riedel thyroiditis (RT), fibrosing variant of Hashimoto thyroiditis (FVHT), IgG4-related Hashimoto thyroiditis, and Graves disease with elevated IgG4 levels. Read More
Thyroid 2012 Sep 24;22(9):964-8. Epub 2012 Jul 24.
Department of Clinical Pathology, Geneva University Hospital, 1 rue Michel-Servet, Geneva, Switzerland.
Background: Riedel's thyroiditis (RT) is a very rare chronic fibrosing disorder of unknown etiology that is often associated with multifocal fibrosclerosis (MFS). Immunoglobulin (Ig) G4-related sclerosing disease (IgG4-RSD), a new clinico-pathological entity also associated with MFS, is characterized by IgG4+ plasma cell infiltration and fibrosis in one or more organs. Although the association of RT and IgG4-RSD has been suggested, it has seldom been studied or reported. Read More
Asia Pac Allergy 2014 Jul 29;4(3):172-6. Epub 2014 Jul 29.
Department of Clinical Immunology, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia.
Background: Immunoglobulin G4 (IgG4)-related sclerosing disease is a recently described clinicopathological entity with diverse manifestations including, amongst others, autoimmune pancreatitis, sclerosing cholangitis, sclerosing sialadenitis and retroperitoneal fibrosis. Elevated serum IgG4 concentration has been described as the hallmark of this condition with reported good sensitivity and specificity.
Objective: We sought to establish the utility of serum IgG4 concentrations in the diagnosis of IgG4-related sclerosing disease by determining how many serum samples with elevated IgG4 from an unselected population would originate from patients who fulfilled criteria for this diagnosis. Read More
J Clin Pathol 2012 Aug 1;65(8):725-8. Epub 2012 Jun 1.
Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.
Hashimoto thyroiditis (HT) and the fibrosing variant of Hashimoto thyroiditis (FVHT) are immune-mediated tumefactive lesions of the thyroid. Immunoglobulin G4-related disease (IgG4-RD) is now a widely recognised multi-organ system disease characterised by elevated serum and tissue concentrations of IgG4. In this study, the authors address several unresolved questions pertaining to the relationship between HT and FVHT, and the association of each of these diseases with IgG4-RD. Read More