Chin Med J (Engl) 2015 Aug;128(16):2228-33
Department of Dermatology, Kurume University School of Medicine, Kurume University Institute of Cutaneous Cell Biology, Kurume, Fukuoka 830-0011, Japan.
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Eur J Pharmacol 2011 May 24;658(2-3):242-7. Epub 2011 Mar 24.
Protein Modification and Degradation Lab, Department of Pathophysiology, Guangzhou Medical College, Guangzhou, Guangdong, PR China.
Shikonin, extracted from medicinal Chinese herb (Lithospermum erythrorhizo), was reported to exert anti-inflammatory and anti-cancer effects both in vitro and in vivo. We have found that proteasome was a molecular target of shikonin in tumor cells, but whether shikonin targets macrophage proteasome needs to be investigated. In the current study, we report that shikonin inhibited inflammation in mouse models as efficiently as dexamethasone. Read More
Br J Pharmacol 2010 May;160(2):376-88
Departament de Farmacologia, Universitat de València, Burjassot, Spain.
Background And Purpose: In the present paper we studied the effect of shikonin on ear oedema induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), and determined the mechanisms through which shikonin might exert its topical anti-inflammatory action.
Experimental Approach: Acute ear oedema was induced in mice by topical application of TPA. The in vitro assays used macrophages RAW 264. Read More
J Pharm Pharmacol 2015 Aug 16;67(8):1143-55. Epub 2015 Apr 16.
Key Laboratory of New Drug Delivery Systems of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing, China.
Objectives: Shikonin is an active naphthoquinone pigment isolated from the root of Lithospermum erythrorhizon. This study was designed to explore the inhibition of Shikonin on cell viability, adhesion, migration and invasion ability of gastric cancer (GC) and its possible mechanism.
Methods: 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was performed for cell viability and adhesion ability of MGC-803 cells. Read More
Can J Physiol Pharmacol 2015 Aug 18;93(8):615-24. Epub 2015 Mar 18.
a Department of Cardiology, The First Affiliated Hospital of China Medical University, 155 North Nanjing Street, Shenyang 110001, People's Republic of China.
Shikonin is a naphthoquinone compound extracted from the Chinese herb purple gromwell. Shikonin has broad antibacterial, anti-inflammatory, and antitumor activities. The tumor necrosis factor-α (TNF-α)-induced proliferation and invasion of vascular smooth muscle cells (VSMCs) is an important factor that contributes to atherosclerosis. Read More