PLoS One 2015 5;10(8):e0134819. Epub 2015 Aug 5.
The Beckman Institute for Advanced Science and Technology at the University of Illinois, Urbana, IL, United States of America.
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PLoS One 2015 8;10(4):e0120315. Epub 2015 Apr 8.
The Beckman Institute for Advanced Science and Technology at the University of Illinois, 405 N. Mathews Ave, Urbana, IL, 61801, United States of America.
Decline in cognitive performance in old age is linked to both suboptimal neural processing in grey matter (GM) and reduced integrity of white matter (WM), but the whole-brain structure-function-cognition associations remain poorly understood. Here we apply a novel measure of GM processing-moment-to-moment variability in the blood oxygenation level-dependent signal (SDBOLD)-to study the associations between GM function during resting state, performance on four main cognitive domains (i.e. Read More
PLoS One 2014 17;9(9):e107413. Epub 2014 Sep 17.
The Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana, Illinois, United States of America.
Physical activity (PA) and cardiorespiratory fitness (CRF) are associated with better cognitive function in late life, but the neural correlates for these relationships are unclear. To study these correlates, we examined the association of both PA and CRF with measures of white matter (WM) integrity in 88 healthy low-fit adults (age 60-78). Using accelerometry, we objectively measured sedentary behavior, light PA, and moderate to vigorous PA (MV-PA) over a week. Read More
Brain Imaging Behav 2015 Sep;9(3):639-49
Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI, 53705 USA.
Cardiorespiratory fitness (CRF) is an objective measure of habitual physical activity (PA), and has been linked to increased brain structure and cognition. The gold standard method for measuring CRF is graded exercise testing (GXT), but GXT is not feasible in many settings. The objective of this study was to examine whether a non-exercise estimate of CRF is related to gray matter (GM) volumes, white matter hyperintensities (WMH), cognition, objective and subjective memory function, and mood in a middle-aged cohort at risk for Alzheimer's disease (AD). Read More
PLoS One 2016 28;11(11):e0167012. Epub 2016 Nov 28.
K.G. Jebsen Center of Exercise in Medicine at Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
Introduction: Physical activity (PA) is beneficial for general health. As a result, adults around the world are recommended to undertake regular PA of either absolute or relative intensity. Traditionally, adherence to PA recommendation is assessed by accelerometers that record absolute intensity thresholds. Read More