Increased incidence of intermittent hypoxemia in the Ts65Dn mouse model of Down syndrome.

Authors:
Dr. Atoossa Fahimi, MD, PsyM
Dr. Atoossa Fahimi, MD, PsyM
Stanford University School of Medicine
Postdoc Fellow/ Research Associate
Psychiatry-Neuroscience
Palo Alto, CA | United States
Dr Mehmet Akif Baktir, MD
Dr Mehmet Akif Baktir, MD
Stanford University School of Medicine
Visiting Researcher
Physiology
Turkey
Prof Ahmad Salehi, M.D., Ph.D.
Prof Ahmad Salehi, M.D., Ph.D.
Stanford University School of Medicine
Professor
Palo Alto, CA | United States

Neurosci Lett 2015 Sep 1;604:91-6. Epub 2015 Aug 1.

VA Palo Alto Health Care System, Palo Alto, CA 94305, USA; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305, USA. Electronic address:

In addition to nervous system, cardiovascular and respiratory systems are primarily affected in Down syndrome (DS). The Ts65Dn mouse model is widely used to recapitulate cognitive dysfunction in DS. While these mice consistently show failure in learning and memory along with functional and structural abnormalities in the hippocampal region, the underlying mechanisms behind cognitive dysfunction remain to be fully elucidated. Convergent evidence implicates chronic episodes of hypoxemia in cognitive dysfunction in people with DS. Using an infra-red detection system to assess oxygen saturation in free-moving mice, we assessed arterial blood oxygenation in both adolescent and adult Ts65Dn mice and found a significant increase in the incidence of hypoxemia in both groups. Notably, the severity of hypoxemia increased during the dark cycle, suggesting a link between hypoxemia and increased motor activity. Postmortem analysis showed significant increase in the expression of mitochondrial Cox4i2, the terminal enzyme of the mitochondrial respiratory chain and oxygen response element. Altogether these data suggest early and chronic occurrence of hypoxemia in the Ts65Dn mouse model of DS, which can contribute to cognitive dysfunction in these mice.

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http://dx.doi.org/10.1016/j.neulet.2015.07.040DOI Listing
September 2015
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2 Citations
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