Quantitative Evaluation of the Substantially Variable Morphology and Function of the Left Atrial Appendage and Its Relation with Adjacent Structures.

Authors:
Xiao-Wei Liu
Xiao-Wei Liu
Central South University
China
Guo-Chao Liu
Guo-Chao Liu
State Key Laboratory of Silkworm Genome Biology
Hai-Qing Yang
Hai-Qing Yang
College of Biosystems Engineering and Food Science
China

PLoS One 2015 31;10(7):e0126818. Epub 2015 Jul 31.

Department of Medical Imaging, Second Hospital, Hebei Medical University, Shijiazhuang, Hebei Province, PR China.

Objective: To investigate quantitatively the morphology, anatomy and function of the left atrial appendage (LAA) and its relation with adjacent structures.

Materials And Methods: A total of 860 patients (533 men, 62.0%, age 55.9±10.4 year) who had cardiac multidetector computed tomography angiography from May to October 2012 were enrolled for analysis.

Results: Seven types and 6 subtypes of LAA morphology were found with Type 2 being the most prevalent. Type 5 was more significantly (P<0.05) present in women (8.0%) than in men (4.2%). LAA orifice was oval in 81.5%, triangular in 7.3%, semicircular in 4%, water drop-like in 3.2%, round in 2.4% and foot-like in 1.6%. The LAA orifice had a significantly greater (P<0.01) major axis in men (24.79±3.81) than in women (22.68±4.07). The LAA orifice long axis was significantly (P<0.05) positively correlated with the height, weight and surface area of the patient. The LAA morphology parameters displayed strong positive correlation with the left atrium volume, aortic cross area long axis or LSPV long axis but poor correlation with the height, weight, surface area and vertebral body height of the patients. Four types of LAA ridge were identified: AI, AII, B and C with the distribution of 17.6%, 69.9%, 5.9% and 6.6%, respectively. The LAA had a significantly (P<0.05) greater distance from its orifice to the mitral ring in women than in men. The LAA had two filling and two emptying processes with the greatest volume at 45% phase but the least volume at 5% phase. The LAA maximal, minimal and emptying volumes were all significantly (P<0.05) positively correlated with the body height, weight and surface area, whereas the LAA ejection fraction had an inverse correlation with the LAA minimal volume but no correlation with the maximal volume.

Conclusion: The LAA has substantially variable morphologies and relation with the adjacent structures, which may be helpful in guiding the LAA trans-catheter occlusion or catheter ablation procedures.

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Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0126818PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521946PMC

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May 2016
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References

(Supplied by CrossRef)
An epidemiological study on the prevalence of atrial fibrillation in the Chinese population of mainland China
Z Zhou et al.
Journal of epidemiology / Japan Epidemiological Association 2008
Atrial fibrillation as an independent risk factor for stroke: the Framingham Study
PA Wolf et al.
Stroke; a journal of cerebral circulation 1991
Prevalence, incidence and lifetime risk of atrial fibrillation in China: New insights into the global burden of atrial fibrillation
Y Guo et al.
Chest 2014
Left atrial appendage: structure, function, and role in thromboembolism
NM Al-Saady et al.
Heart (British Cardiac Society) 1999

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