Good at Heart: Preserving Cardiac Metabolism during aging.

Authors:
Daniela Sorriento
Daniela Sorriento
Department of Clinical Medicine
Italy
Antonietta Franco
Antonietta Franco
Washington University School of Medicine
Italy
Maria Rosaria Rusciano
Maria Rosaria Rusciano
University of Naples Federico II
Italy
Angela Serena Maione
Angela Serena Maione
University of Naples Federico II
Italy
Maria Soprano
Maria Soprano
Federico II University
Napoli | Italy
Maddalena Illario
Maddalena Illario
University of Naples Federico II
Napoli | Italy
Prof. Guido Iaccarino, MD, PhD
Prof. Guido Iaccarino, MD, PhD
Federico II University of Naples
Full Professor of Applied Medical Science and Technology
Cardiology
Napoli, Campania | Italy
Michele Ciccarelli
Michele Ciccarelli
University of Salerno
Fisciano | Italy

Curr Diabetes Rev 2015 ;12(2):90-9

Department of Medicine and Surgery, University of Salerno, Italy.

The natural process of aging determinates several cardiac modifications with increased susceptibility to heart diseases and ultimately converging on development of chronic heart failure as final stage. These changes mainly include left ventricular hypertrophy, diastolic dysfunction, valvular degeneration, increased cardiac fibrosis, increased prevalence of atrial fibrillation, and decreased maximal exercise capacity, as demonstrated in several humans and animal models of aging. While different theories have been proposed to explain the natural process of aging, it is clear that most of the alterations affect mechanisms involved in cell homeostasis and maintenance. Latest research studies have in particular focused on role of mitochondrial oxidative stress, energy production and mitochondria quality control. This article reviews the central role played by this organelle in aging and the role of new molecular players involved into the progression toward heart failure and potentially susceptible of new "anti-aging" strategies.

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Source
September 2016
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