PAX5-expressing ALK-negative anaplastic large cell lymphoma with extensive extranodal and nodal involvement.

BMJ Case Rep 2015 Jul 17;2015. Epub 2015 Jul 17.

Alfred Pathology Service, Alfred Health, Melbourne, Victoria, Australia Department of Haematology, Monash Health, Clayton, Victoria, Australia.

A 55-year-old man with a history of well controlled HIV infection was admitted with acute renal impairment, peripheral oedema, constitutional symptoms, deranged liver function and hypercalcaemia. Core biopsies of a retroperitoneal mass demonstrated anaplastic lymphoma kinase (ALK) negative anaplastic large cell lymphoma (ALCL) with unusual Paired box 5 (PAX5) positivity. The same malignant cells were identifiable on urine cytology. Staging investigations revealed extensive nodal and extranodal disease including ALK negative ALCL involving the kidney and prostate, which has not previously been reported in the published literature.

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Source
http://casereports.bmj.com/lookup/doi/10.1136/bcr-2015-21115
Publisher Site
http://dx.doi.org/10.1136/bcr-2015-211159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513530PMC
July 2015

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