Epigenome data release: a participant-centered approach to privacy protection.

Genome Biol 2015 Jul 17;16:142. Epub 2015 Jul 17.

Department of Human Genetics, McGill University and Genome Quebec Innovation Centre, Montreal, QC, H3A 0G1, Canada.

Large-scale epigenome mapping by the NIH Roadmap Epigenomics Project, the ENCODE Consortium and the International Human Epigenome Consortium (IHEC) produces genome-wide DNA methylation data at one base-pair resolution. We examine how such data can be made open-access while balancing appropriate interpretation and genomic privacy. We propose guidelines for data release that both reduce ambiguity in the interpretation of open-access data and limit immediate access to genetic variation data that are made available through controlled access.

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13059-015-0723-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504083PMC
July 2015
57 Reads

Publication Analysis

Top Keywords

data release
8
data
5
data open-access
4
examine data
4
open-access balancing
4
balancing appropriate
4
interpretation genomic
4
appropriate interpretation
4
resolution examine
4
data base-pair
4
ihec produces
4
consortium ihec
4
produces genome-wide
4
genome-wide dna
4
genomic privacy
4
methylation data
4
base-pair resolution
4
privacy propose
4
access genetic
4
limit access
4

Altmetric Statistics

Similar Publications