The Significance of the Discordant Occurrence of Lens Tumors in Humans versus Other Species.

Authors:
Daniel M Albert
Daniel M Albert
University of Wisconsin School of Medicine and Public Health
Madison | United States
Dr. Paul O Phelps, MD
Dr. Paul O Phelps, MD
NorthShore University HealthSystem
Attending Surgeon
Ophthalmology, Ophthalmic Plastic and Reconstructive Surgery, Ophthalmic Pathology
Chicago, IL | United States
Krishna R Surapaneni
Krishna R Surapaneni
University of Wisconsin - Madison
Madison | United States
Bradley A Thuro
Bradley A Thuro
The University of Texas MD Anderson Cancer Center
Houston | United States
Akihiro Ikeda
Akihiro Ikeda
University of Wisconsin-Madison
Richard R Dubielzig
Richard R Dubielzig
School of Veterinary Medicine
Madison | United States

Ophthalmology 2015 Sep 27;122(9):1765-70. Epub 2015 Jun 27.

Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin.

Purpose: The purpose of this study was to determine in which species and under what conditions lens tumors occur.

Design: A review of databases of available human and veterinary ocular pathologic material and the previously reported literature.

Participants: Approximately 18 000 patients who had ocular surgical specimens submitted and studied at the University of Wisconsin School of Medicine and Public Health between 1920 and 2014 and 45 000 ocular veterinary cases from the Comparative Ocular Pathology Laboratory of Wisconsin between 1983 and 2014.

Methods: Material in 2 major archived collections at the University of Wisconsin medical and veterinary schools were studied for occurrence of lens tumors. Tumor was defined as a new growth of tissue characterized by progressive, uncontrolled proliferation of cells. In addition, cases presented at 3 major eye pathologic societies (Verhoeff-Zimmerman Ophthalmic Pathology Society, Eastern Ophthalmic Pathology Society, and The Armed Forces Institute of Pathology Ophthalmic Alumni Society) from 1975 through 2014 were reviewed. Finally, a careful search of the literature was carried out. Approval from the institutional review board to carry out this study was obtained.

Main Outcome Measures: The presence of tumors of the lens.

Results: The database search and literature review failed to find an example of a lens tumor in humans. In contrast, examples of naturally occurring lens tumors were found in cats, dogs, rabbits, and birds. In the veterinary school database, 4.5% of feline intraocular and adnexal neoplasms (234/5153) were designated as feline ocular posttraumatic sarcoma, a tumor previously demonstrated to be of lens epithelial origin. Similar tumors were seen in rabbit eyes, a bird, and in a dog. All 4 species with lens tumors had a history of either ocular trauma or protracted uveitis. The literature search also revealed cases where lens tumors were induced in zebrafish, rainbow trout, hamsters, and mice by carcinogenic agents (methylcholanthrene, thioacetamide), oncogenic viruses (SV40, HPV-16), and genetic manipulation.

Conclusions: Our results suggest that lens tumors do not occur in humans. In contrast, after lens capsule rupture, a lens tumor can occur in other species. We hypothesize that a genetic mechanism exists that prevents lens tumors in humans.

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Source
http://dx.doi.org/10.1016/j.ophtha.2015.05.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549210PMC
September 2015
42 Reads
1 Citation
6.135 Impact Factor

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