Ann N Y Acad Sci 2015 Sep 23;1350:48-51. Epub 2015 Jun 23.
Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.
It is now possible to functionally impair mitochondria through light illumination with high specificity. These optogenetic tools permit precise control on the timing, location, and extent of mitochondrial damage within a cell population with subcellular resolution, allowing quantitative probing of the various types of mitochondrial damage responses within cells. This approach can generally be extended toward the probing of other organelle damage responses.