Untreated Mild Hyperglycemia During Pregnancy and Anthropometric Measures of Obesity in Offspring at Age 5-7 Years.

Diabetes Care 2015 Sep 19;38(9):1701-6. Epub 2015 Jun 19.

Royal Victoria Hospital, Belfast, U.K. Queen's University Belfast, Belfast, U.K. Royal Jubilee Maternity Hospital, Belfast, U.K.

Objective: Obesity in the offspring of women with hyperglycemia during pregnancy has been reported, but the results are conflicting. This study examined the association of hyperglycemia during pregnancy and anthropometry in 5- to 7-year-old offspring whose mothers participated in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study at the Belfast Centre.

Research Design And Methods: Women in the HAPO study underwent a 75-g oral glucose tolerance test (OGTT) at approximately 28 weeks of gestation. Mothers and caregivers remained blinded to the results unless the fasting plasma glucose (FPG) concentration was >5.8 mmol/L or the 2-h plasma glucose (2hPG) concentration was >11.1 mmol/L. Offspring weight, height, and skinfold thicknesses (triceps, subscapular, and suprailiac) were measured at age 5-7 years. Overweight, obesity, and extreme obesity were defined as a BMI z score ≥85th, ≥95th, and ≥99th percentile, respectively, based on the 1990 British Growth Standard.

Results: Belfast HAPO offspring (n = 1,320, 82%) aged 5-7 years attended for follow-up. With use of multiple regression, maternal FPG, 1h PG, and 2hPG did not show any relation to offspring BMI z score or offspring skinfold sum independent of maternal BMI at OGTT and offspring birth weight z score. This lack of association with maternal glycemia persisted with the offspring BMI z score expressed as ≥85th, ≥95th, or 99th percentile and the sum of skinfolds expressed as ≥90th percentile specific for sex. The initially significant relation between FPG and all offspring adiposity measures was explained by maternal BMI at the OGTT.

Conclusions: After adjustment for maternal BMI at the OGTT, higher maternal FPG concentration during pregnancy (short of diabetes) is no longer a risk factor for obesity, as reflected by BMI and the sum of skinfolds in offspring aged 5-7 years.

Download full-text PDF

Source
http://dx.doi.org/10.2337/dc14-2797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542272PMC
September 2015
6 Reads

Publication Analysis

Top Keywords

5-7 years
16
maternal bmi
12
hyperglycemia pregnancy
12
bmi score
12
offspring
11
bmi ogtt
8
offspring bmi
8
sum skinfolds
8
aged 5-7
8
fpg concentration
8
plasma glucose
8
≥85th ≥95th
8
age 5-7
8
maternal fpg
8
hapo study
8
obesity offspring
8
bmi
7
maternal
6
pregnancy
5
obesity
5

Similar Publications