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Biosci Rep 2021 Feb 24. Epub 2021 Feb 24.

University of São Paulo, Sao Paulo, Brazil.

Since the emergence of the new severe acute respiratory syndrome-related coronaviruses 2 (SARS-CoV-2) at the end of December 2019 in China, and with the urge of the coronavirus disease 2019 (COVID-19) pandemic, there have been a huge effort of many research teams and governmental institutions worldwide to mitigate the current scenario. Reaching more than 1,377,000 deaths in the world and still with a growing number of infections, SARS-CoV-2 remains a critical issue for global health and economic systems, with an urgency for available therapeutic options. In this scenario, as drug repurposing and discovery remains a challenge, computer-aided drug design (CADD) approaches, including machine learning (ML) techniques, can be useful tools to the design and discovery of novel potential antiviral inhibitors against SARS-CoV-2. Read More

Eur J Prev Cardiol 2020 Nov 6. Epub 2020 Nov 6.

Department of Translational Medical Sciences, University of Naples "Federico II", Via Sergio Pansini 5, Naples 80131, Italy.

Along with epidemiologic transitions of the global population, the burden of aortic stenosis (AS) is rapidly increasing and transcatheter aortic valve replacement (TAVR) has quickly spread; indeed, it is nowadays also employed in treating patients with AS at intermediate operative risk. Nonetheless, the less invasive interventional strategy still carries relevant issues concerning post-procedural optimal antithrombotic strategy, given the current indications provided by guidelines are not completely supported by evidence-based data. Geriatric patients suffer from high bleeding and thromboembolic risks, whose balance is particularly subtle due to the presence of concomitant conditions, such as atrial fibrillation and chronic kidney disease, that make the post-TAVR antithrombotic management particularly insidious. Read More

Research (Wash D C) 2020 9;2020:7158953. Epub 2020 Nov 9.

Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.

The parallel evolution of wearable electronics, artificial intelligence, and fifth-generation wireless technology has created a technological paradigm with the potential to change our lives profoundly. Despite this, addressing limitations linked to continuous, sustainable, and pervasive powering of wearable electronics remains a bottleneck to overcome in order to maximize the exponential benefit that these technologies can bring once synergized. A recent groundbreaking discovery has demonstrated that by using the coupling effect of contact electrification and electrostatic induction, triboelectric nanogenerators (TENGs) can efficiently convert irregular and low-frequency passive biomechanical energy from body movements into electrical energy, providing an infinite and sustainable power source for wearable electronics. Read More

Indian J Palliat Care 2020 Oct-Dec;26(4):405-410. Epub 2020 Nov 19.

Department of Oncology, Merck Specialities Pvt. Ltd., India, Merck KGaA, Darmstadt, Germany.

It is often difficult for people with cancer to make decisions for their care. The aim of this review is to understand the importance of shared decisionmaking (SDM) in Indian clinical scenario and identify the gaps when compared to practices in the Western world. A systematic search (2000-2019) was executed in Medline and Google Scholar using predefined keywords. Read More

Matern Child Nutr 2021 Feb 23:e13118. Epub 2021 Feb 23.

Research unit, Expertise & Advocacy Department, Action Contre la Faim, Paris, France.

Ready-to-use therapeutic foods (RUTF) used to treat children with severe acute malnutrition (SAM) are costly, and the prescribed dosage has not been optimized. The MANGO trial, implemented by Action Contre la Faim in Burkina Faso, proved the non-inferiority of a reduced RUTF dosage in community-based treatment of uncomplicated SAM. We performed a cost-minimization analysis to assess the economic impact of transitioning from the standard to the reduced RUTF dose. Read More