Role of c-Maf in Chondrocyte Differentiation: A Review.

Authors:
Eunmee Hong
Eunmee Hong
Lawrence Ellison Center for Tissue Regeneration and Repair
Davis | United States
Prof. Dominik R Haudenschild, Ph.D.
Prof. Dominik R Haudenschild, Ph.D.
University of California Davis Medical Center
Professor
Arthritis Research
Sacramento, CA | United States

Cartilage 2011 Jan;2(1):27-35

University of California Davis Medical Center, Division of Orthopaedic Research, Department of Orthopaedic Surgery, Sacramento, CA, USA.

Chondrocyte differentiation in the growth plate is an important process for the longitudinal growth of endochondral bones. Sox9 and Runx2 are the most often-studied transcriptional regulators of the chondrocyte differentiation process, but the importance of additional factors is also becoming apparent. Mafs are a subfamily of the basic ZIP (bZIP) transcription factor superfamily, which act as key regulators of tissue-specific gene expression and terminal differentiation in many tissues. There is increasing evidence that c-Maf and its splicing variant Lc-Maf play a role in chondrocyte differentiation in a temporal-spatial manner. This review summarizes the functions of c-Maf in chondrocyte differentiation and discusses the possible role of c-Maf in osteoarthritis progression.

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Source
http://dx.doi.org/10.1177/1947603510377464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300789PMC

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January 2011
16 Reads
2 Citations

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