Pubfacts - Scientific Publication Data
  • Categories
  • |
  • Journals
  • |
  • Authors
  • Login
  • Categories
  • Journals

Search Our Scientific Publications & Authors

Publications
  • Publications
  • Authors
find publications by category +
Translate page:

Sustained Domestic Vector Exposure Is Associated With Increased Chagas Cardiomyopathy Risk but Decreased Parasitemia and Congenital Transmission Risk Among Young Women in Bolivia.

Authors:
Michelle Kaplinski Malasa Jois Gerson Galdos-Cardenas Victoria R Rendell Vishal Shah Rose Q Do Rachel Marcus Melissa S Burroughs Pena Maria del Carmen Abastoflor Carlos LaFuente Ricardo Bozo Edward Valencia Manuela Verastegui Rony Colanzi Robert H Gilman Caryn Bern

Clin Infect Dis 2015 Sep 9;61(6):918-26. Epub 2015 Jun 9.

Department of Epidemiology and Biostatistics, University of California, San Francisco School of Medicine.

Background: We studied women and their infants to evaluate risk factors for congenital transmission and cardiomyopathy in Trypanosoma cruzi-infected women.

Methods: Women provided data and blood for serology and quantitative polymerase chain reaction (PCR). Infants of infected women had blood tested at 0 and 1 month by microscopy, PCR and immunoblot, and serology at 6 and 9 months. Women underwent electrocardiography (ECG).

Results: Of 1696 women, 456 (26.9%) were infected; 31 (6.8%) transmitted T. cruzi to their infants. Women who transmitted had higher parasite loads than those who did not (median, 62.0 [interquartile range {IQR}, 25.8-204.8] vs 0.05 [IQR, 0-29.6]; P < .0001). Transmission was higher in twin than in singleton births (27.3% vs 6.4%; P = .04). Women who had not lived in infested houses transmitted more frequently (9.7% vs 4.6%; P = .04), were more likely to have positive results by PCR (65.5% vs 33.9%; P < .001), and had higher parasite loads than those who had lived in infested houses (median, 25.8 [IQR, 0-64.1] vs 0 [IQR, 0-12.3]; P < .001). Of 302 infected women, 28 (9.3%) had ECG abnormalities consistent with Chagas cardiomyopathy; risk was higher for older women (odds ratio [OR], 1.06 [95% confidence interval {CI}, 1.01-1.12] per year) and those with vector exposure (OR, 3.7 [95% CI, 1.4-10.2]). We observed a strong dose-response relationship between ECG abnormalities and reported years of living in an infested house.

Conclusions: We hypothesize that repeated vector-borne infection sustains antigen exposure and the consequent inflammatory response at a higher chronic level, increasing cardiac morbidity, but possibly enabling exposed women to control parasitemia in the face of pregnancy-induced Th2 polarization.

Download full-text PDF

Source
http://dx.doi.org/10.1093/cid/civ446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551010PMC
September 2015

Publication Analysis

Top Keywords

women
11
lived infested
8
cardiomyopathy risk
8
congenital transmission
8
chagas cardiomyopathy
8
infected women
8
infested houses
8
vector exposure
8
parasite loads
8
higher parasite
8
ecg abnormalities
8
higher
5
46% positive
4
001 higher
4
positive pcr
4
pcr 655%
4
655% 339%
4
339% 001
4
258 [iqr
4
loads lived
4

Keyword Occurance

Similar Publications

Pragmatic, Data-Driven Method to Determine Cutoffs for CSF Biomarkers of Alzheimer Disease Based on Validation Against PET Imaging.

Authors:
Julien Dumurgier Séverine Sabia Henrik Zetterberg Charlotte Teunissen Bernard Hanseeuw Adelina Orellana Susanna Schraen Audrey Gabelle Mercè Boada Thibaud Lebouvier Eline A J Willemse Emmanuel Cognat Agustin Ruiz Claire Hourregue Matthieu Lilamand Elodie Bouaziz-Amar Jean-Louis Laplanche Sylvain Lehmann Florence Pasquier Philip Scheltens Kaj Blennow Archana Singh-Manoux Claire Paquet

Neurology 2022 May 26. Epub 2022 May 26.

Cognitive Neurology Center, Lariboisiere - Fernand Widal Hospital, AP-HP, Université de Paris, Paris, France.

Objective: To elaborate a new algorithm to establish a standardized method to define cuff-offs for CSF biomarkers of Alzheimer's disease (AD) by validating the algorithm against CSF classification derived from PET imaging.

Methods: Low and high levels of CSF phosphorylated tau were first identified to establish optimal cut-offs for CSF amyloid-β peptide (Aβ) biomarkers. These Aβ cut-offs were then used to determine cut-offs for CSF tau and phosphorylated tau markers. Read More

View Article and Full-Text PDF
May 2022
Similar Publications

Early career Black women in school-based mental health fields: Understanding their experiences of workplace discrimination.

Authors:
Janise S Parker Natoya Haskins Antony Clemons Erin McClure Jessica Washington

J Sch Psychol 2022 Jun 8;92:49-65. Epub 2022 Mar 8.

William and Mary, United States of America.

This study aimed to understand school mental health providers' experiences with racism and other forms of discrimination (i.e., gendered-based discrimination) at work, with an exclusive focus on early career Black women. Read More

View Article and Full-Text PDF
June 2022
Similar Publications

Does time-lapse monitoring improve outcomes compared with conventional morphological assessment in women undergoing in vitro fertilization/intracytoplasmic sperm injection?

Authors:
Russell S Kirby

Fertil Steril 2022 Jun;117(6):1213

College of Public Health, University of South Florida, Tampa, Florida.

View Article and Full-Text PDF
June 2022
Similar Publications

Evidence for the effectiveness of immunologic therapies in women with subfertility and/or undergoing assisted reproduction.

Authors:
Pedro Melo Teresa Thornton Arri Coomarasamy Ingrid Granne

Fertil Steril 2022 Jun;117(6):1144-1159

Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, United Kingdom. Electronic address:

Implantation is a critical step in the establishment of a successful pregnancy, depending on a complex immune-endocrine dialogue between the developing embryo and maternal endometrium. Research suggests that altered immunity in the maternal decidua results in implantation impairment and failure. Immunomodulatory drugs have, thus, been widely used in assisted conception to aid embryo implantation, despite an absence of consensus on their effectiveness and safety. Read More

View Article and Full-Text PDF
June 2022
Similar Publications
}
© 2022 PubFacts.
  • About PubFacts
  • Privacy Policy
  • Sitemap